Heat Stable Nanoparticle Amplified Immunoassays

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: W31P4Q-08-C-0030
Agency Tracking Number: 07SB2-0073
Amount: $98,972.00
Phase: Phase I
Program: SBIR
Awards Year: 2007
Solicitation Year: 2007
Solicitation Topic Code: SB072-006
Solicitation Number: 2007.2
Small Business Information
111 Downey Street, Norwood, MA, 02062
DUNS: 076603836
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Michael Wilson
 Senior Scientist
 (781) 769-9450
Business Contact
 R. Rauh
Title: President
Phone: (781) 769-9450
Email: drauh@eiclabs.com
Research Institution
The theater of operation for DoD immunoassays typically requires them to be sensitive, stable at temperatures up to 35 oC for up to two years, and be low power or power-free. Although enzyme-based assays are very sensitive, enzymes are usually unstable under such storage conditions. We propose a new photocatalytic nanoparticle-based immunoassay method that provides the amplification associated with enzyme-based assays but without the instability problems associated with enzymes. The method can be readily adapted to lateral flow immunoassays, which provide convenient testing in the field, but often suffer from poor sensitivity. In addition, the technology can also be used in biosensors and lab-based immunoassays.

* Information listed above is at the time of submission. *

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