Improving the stability and concentration of Megasphaera elsdenii NCIMB 41125

Award Information
Agency: Department of Agriculture
Branch: N/A
Contract: N/A
Agency Tracking Number: 2010-00594
Amount: $90,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solicitation Year: N/A
Solicitation Topic Code: 8.3
Solicitation Number: N/A
Small Business Information
1306 8TH ST, Wamego, KS, 66547
DUNS: 831583815
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Matthew May
 (719) 349-1365
Business Contact
 Matthew May
Title: Research/Development
Phone: (719) 349-1365
Research Institution
Acidosis in ruminant animals (beef cattle, dairy cows, and sheep)is a metabolic condition that causes problems for animals fed high-grain diets. Orally dosing animals with a strain of bacteria, Megasphaera elsdenii, has been shown to be beneficial in alleviating or decreasing this metabolic problem. This bacteria is very sensitive to environments containing oxygen and to date has a fairly short shelf life of 14 days. The goal of our research is first to optimize the growth rate of the organism by modifying the solution in which it is grown. Secondly, to increase the stability and survival rate of the organism by modifying the solution in which it is stored. Lastly, to concentrate the current dose size by improved growth rate and filtration. It is also important to evaluate the survival rate of the organim in a variety of temperatures in which it could face during transit and subsequent storage at each respective farm. Many of the solutes that will be added to the growth solution or storage solution have been shown to be protective of bacteria to high osmotic pressure and temperature changes in the environment. Once the product is cleared, improving the currnet product will allow for greater market share, improved ease for farmers, ranchers, and producers utilizing the product.

* Information listed above is at the time of submission. *

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