IN VIVO EVALUATION OF ULTRASOUND ENHANCED LYSIS

One method of treating occluded arteries and grafts is through the infusion of thrombolytic agents. This treatment is sometimes ineffective, remains costly, and time consuming. Tachibana and others have demonstrated that ultrasound dramatically enhances the action of thrombolytic agents on clot dissolution. $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 425 --PROJECT NUMBER......1 R43 HL57755-01 INVESTIGATOR NAME/ADDRESS FY 97 XIAO, T DANNY IRG/INTRAMURAL UNIT..ZRG7 US NANOCORP, INC AWARD AMOUNT......... $97,737 20 WASHINGTON AVE, SUITE 106 NORTH HAVEN, CT 06473-2342 PERFORMING ORGANIZATION: US NANOCORP, INC. TITLE NANOPHASE ELECTRODE MATERIALS FOR HIGH ENERGY BATTERY ABSTRACT: Ventricular Assist Devices (VADs) have a critical need for high performance rechargeable batteries, both implantable and external. High energy density (volumetric for implantable and gravimetric for external) and long cycle life are essential. Clearly, issues of safety and quality control are paramount, especially for implant able applications. US Nanocorp, Inc. (USN) has been created to commercialize a new class of "nanophase" materials (i.e. atomic-scale particles on the order of several nanometers) as the active ingredients for high performance rechargeable alkaline batteries. The principals of US Nanocorp, Inc. have developed proprietary innovative materials processes for the synthesis of nanostructured materials that are anticipated to improve battery energy density, cycle life, and rate capability as well as reduce the manufacturing cost of the active materials. This novel approach can be applied to a wide array of battery materials, including nickel hydroxide, Ni(OH) 2, and manganese dioxide, Mn02, both of which are presently used in consumer batteries. The proposed program will focus on fabrication of these two materials in nanophase form. USN and a strategic partner (Electro Energy, Inc.) will evaluate these materials in bipolar Ni-MM and Mn02-MH batteries using EEI's unique stackable wafer cell geometry. Feasibility will be demonstrated and an optimal system will be chosen for Phase II development/commercialization.