Conductivity Analysis for Improved High-Resolution EEG

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43NS056758-01
Agency Tracking Number: NS056758
Amount: $98,913.00
Phase: Phase I
Program: SBIR
Awards Year: 2006
Solicitation Year: 2006
Solicitation Topic Code: N/A
Solicitation Number: PHS2006-2
Small Business Information
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (541) 346-0453
Business Contact
Phone: (541) 687-7962
Research Institution
DESCRIPTION (provided by applicant): Electroencephalography (EEG) is an indispensable neurological diagnostic tool in terms of fast time scale, portability, and cost efficiency. Improved spatial resolution of EEG measures would greatly benefit clinical and research applications, including stroke, epilepsy, and cognitive studies. Dense-array EEG recordings can be used to localize cortical function, providing a unique opportunity for monitoring brain activity both in space and time. Localizing brain function using EEG can be further optimized by use of realistic head models and incorporating accurate conductivity estimates for each tissue type of the head model. Lack of accurate skull conductivity information is particularly problematic given the variations in skull development from infancy through adolescence. The goal of this project is to develop technology for conductivity estimation to guide EEG source localization. This Phase I project will quantify systematic bias in EEG source localization due to conductivity misspecifications and structural uncertainties and demonstrate the feasibility of noninvasive conductivity estimation of major head tissues using parameterized electrical impedance tomography measurements and realistic head geometry in computational models. This will lead to development of a product that will be able to non- invasively determine tissue conductivities, and when coupled with dense-array EEG, will provide unique functional information about brain state. The product innovation proposed in this project would improve the utility of EEG to not only perform functional assessment of the brain but also to accurately localize brain function. This technology will be affordable and portable. Consequently, EEG will be applicable to the management of many neurological disorders, such as epilepsy and stroke, which require acute assessment as well as continuous brain monitoring.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government