ELECTROFUSION AND ELECTROPERMEATION OF CELLS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$48,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
7282
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Electrocell
Western Ny Technology Dev Ctr, 2211 Main Street, Buffalo, NY, 14214
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
HILDA LIANG
(716) 831-3472
Business Contact:
() -
Research Institution:
n/a
Abstract
THE TECHNIQUE OF ELECTROPORATION IS UTILIZED TO PERMEATE CELL MEMBRANES TO INTRODUCE DRUGS OR FOREIGN GENETIC MATERIALS INTO LIVING CELLS. ELECTROFUSION IS USED AS A NEWAPPROACH TO FORM HYBRID CELLS FOR GENETICS STUDIES AND FOR MONOCLONAL ANTIBODY PRODUCTION, AS WELL AS FOR DRUG INFUSIONVIA LIPOSOMES. ELECTROCELL PLANS TO DEVELOP PROTOCOLS FOR ELECTROPORATION AND ELECTROFUSION OF COMMON CELL TYPES, BASED ON THE PHYSICAL PROPERTIES OF CELLS. PROTOTYPES OF THE ELECTRONIC CELL FUSER AND PORATOR WILL BE DESIGNED ACCORDING TO ELECTROCELL'S PROTOCOLS. MICROSCOPIC, MACROSCOPIC, AND CONTINUOUS-FLOW CELL-FUSION CHAMBERS WILL BE MADE. THE SUCCESSFUL DEVELOPMENT OF BOTH HARDWARE AND SOFTWARE PROCEDURES AND FORMULAE WILL FORM THE BASIS FOR COMMERCIALIZATION. THE BIOMEDICAL COMMUNITY IN BUFFALO, NEW YORK, PROVIDES AN EXCELLENT ENVIRONMENT FOR BIOTECHNOLOGY TRANSFER AND FEEDBACK, AS WELL AS A TEST MARKET FOR FUTURE EXPANSION.

* information listed above is at the time of submission.

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