SYNTHESIS OF QINGHAOSU ANALOGUES AS POTENTIAL ANTIPARASITIC AGENTS

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$50,000.00
Award Year:
1989
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
9673
Agency Tracking Number:
9673
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Po Box 430, East Amherst, NY, 14051
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr Duane J Mazur
(716) 684-0513
Business Contact:
() -
Research Institution:
n/a
Abstract
THE SYNTHESIS OF A SERIES OF QINGHAOSU ANALOGUES AS POTENTIAL ANTIPARASITIC AGENTS IS PROPOSED. THESE MATERIALS WILL INCORPORATE THE UNIQUE LACTONE ENDOPEROXIDE FUNCTION ESSENTIAL FOR THE ACTIVITY OF THE PARENT STRUCTURE. THE SYNTHETIC APPROACHES ARE BASED ON WELL-FOUNDED CHEMICAL PRINCIPLES, UTILIZE INEXPENSIVE STARTING MATERIALS, AND SHOULD PROVIDE THE DESIRED COMPOUNDS IN SUFFICIENT QUANTITIES FOR USAMRDC IN VITRO AND IN VIVO BIOLOGICAL EVALUATION PHASE II WILL EXTEND THESE STUDIES TO DEVELOP EVEN MORE ACTIVE ANALOGUES, AS WELL AS TO PRODUCE LARGER QUANTITIES OF PROMISING COMPOUNDS FOR FURTHER TESTING.

* information listed above is at the time of submission.

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