RNA Resource for Synthetic Lethal Screening of DNA Repair and

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N43OD201000077
Agency Tracking Number: N43OD201000077
Amount: $199,918.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solicitation Year: 2010
Solicitation Topic Code: OPPNE
Solicitation Number: PHS2010-1
Small Business Information
ALLELE BIOTECHNOLOGY AND PHARMACEUTICALS
9924 Mesa Rim Road, SAN DIEGO, CA, 92121-2910
DUNS: 021345447
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: Y
Principal Investigator
 Jiwu Wang
Business Contact
Phone: (858) 587-6645
Email: jiwuwang@allelebiotech.com
Research Institution
N/A
Abstract
The objectives of this proposal are to develop gene silencing reagents, and to test/validate their use in synthetic lethal screening of DNA damage signaling and repair pathways. Making such reagents available will provide the efficiency and convenience that cancer researchers currently need to find novel strategies and therapeutics against cancer. DNA repair pathway genes have been shown to encode important factors in cancer biogenesis. Targeting different networks within this pathway may be a promising point of action for curing cancer. The proposed research can facilitate the efforts in finding such cures. The research plan includes a novel combination of a number of essential elements, for example, highly efficient construction of lentiviruses carrying shRNA and use of surrogate targets for gene silencing assays.

* information listed above is at the time of submission.

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