Development of Taenia Solium Specific Aptamers for Diagnostic Assays

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 200-2018-M-03281
Agency Tracking Number: 200-2018-M-03281
Amount: $149,875.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: ODCDC
Solicitation Number: N/A
Timeline
Solicitation Year: 2018
Award Year: 2018
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
2501 Earl Rudder Freeway S., College, TX, 77845-7384
DUNS: 184758308
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Rachel Jordan
 (979) 764-2200
 rachel.jordan@lynntech.com
Business Contact
 Rachel Jordan
Phone: (979) 764-2200
Email: rachel.jordan@lynntech.com
Research Institution
N/A
Abstract
The parasitic tapeworm Taenia solium causes two diseasestaeniasisadult worm in the intestineand cysticercosistissue infection by the cystwhich can lead to seizuresThe Tsolium life cycle involves both humans and pigshowever humans are the only definitive host for the adult Tsolium tapewormDiagnosing people infected with the adult worm is a critical step toward eliminating Tsolium althogetherHoweverit is difficult to identify carriers of Tsolium adult tapewormsDevelopment of Tsolium specific diagnostic assays for the laboratory and at the point of care would lead to diagnosis and treatment of this often asymptomatic conditionImproving diagnosis would lead to treatment that will interrupt the parasite life cycle and encourage eliminationof this diseaseAptamers can provide Tsolium specificity in multiple diagnostic platformsLynntech proposes to develop and identifyTsolium specific aptamers for use in new ELISA and dipstick taeniasis diagnostic assaysThese aptamers will be developed to bind Tsolium coproantigens in stool samplesthen tested for use in sandwich assaysThese aptamers are the first step toward the development of new assays that will help in the fight to eradicate Tsolium infection by diagnosing taeniasis in the United States and abroad

* Information listed above is at the time of submission. *

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