Development of Rapid Antigen Detection Assays For Taeniasis

Development of Rapid Antigen Detection Assays For Taeniasis

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 200-2018-M-03279
Agency Tracking Number: 200-2018-M-03279
Amount: $150,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2018
Solicitation Year: 2018
Solicitation Topic Code: ODCDC
Solicitation Number: N/A
Small Business Information
30 Russell Road, Wellesley, MA, 02482-4316
DUNS: 080462707
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Andrew Levin
 (617) 834-0950
 alevin@kepheradx.com
Business Contact
 Andrew Levin
Phone: (617) 834-0950
Email: alevin@kepheradx.com
Research Institution
N/A
Abstract
This proposal addresses the significant public health threat posed by the spread of Taenia soliumthe pork tapewormin at risk human populationsInfection with Tsoliumor Taeniasiscan lead to Cysticercosiscaused by the migration and encystment of larval Tsolium in the central nervous systemCysticercosis is a severe to fatal disease which affects overmillion people worldwideprincipally in less developed countries where pigs and humans live in close proximityTaeniasis can be treated effectively in individuals who are diagnosed as carriers of the parasitepreventing its spread to othersDiagnostic tests that can detect carriers of Tsolium are not readily available and those that have been developed previously are either complexperform suboptimallyor are not available commerciallyTsolium antigens with high sensitivity and specificity for Taeniasis have been identifiedThis project will focus on the development of specific antibodies to these antigens in Phase Iand on the subsequent use of these antibodies as antigen capture reagents to develop sensitivespecificsimple and rapid tests for Taeniasis in Phase IIThe resulting ELISA and lateral flow assays will be the first highly accurate tests for Taeniasis to be made available commercially

* Information listed above is at the time of submission. *

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