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Synergistic Antifungal Cocktails for Corneal Storage

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 75D30118PO2613
Agency Tracking Number: 75D30118PO2613
Amount: $149,983.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: ODCDC
Solicitation Number: N/A
Solicitation Year: 2018
Award Year: 2018
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
89 Rumford Ave, Newton, MA, 78152
DUNS: 066594979
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Avni Argun
 (781) 529-0581
Business Contact
 Avni Argun
Phone: (781) 529-0581
Research Institution
Fungal endophthalmitis is an infection inside the eye after corneal transplant surgery caused by contamination of the transplanted tissueAccording to the Eye Bank of Americathe incidence of postsurgery endophthalmitis more than doubled fromtoand thatof the culture positive cases were due to Candida yeastEnvironmental contamination as well as current corneal preservation conditions contribute to the proliferation of fungiSolutions used for transportation and storage of donor cornea may therefore benefit from addition of antifungal drugs to prevent infectionsUsing a rapid and cost effective screening methodsynergistic combinations of multiple drugs will be developed and an antifungal cocktail will be formulated to achieve high efficacy against Candida species at low dosesminimizing negative impact on corneal tissueAntifungal performance and corneal tissue viability will be validated by assessment of storage stabilitysafety against the corneal tissueand antifungal spectrumBy using synergistic combinations of multiple drugsdose and associated toxicity will be decreased

* Information listed above is at the time of submission. *

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