Topic 371: Validation and Optimization of RP-185 as Adjuvant to Exploit the Immune Response Generated by Radiation

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 75N91018C00023-0-0-0
Agency Tracking Number: N43CA180023
Amount: $299,847.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NCI
Solicitation Number: N/A
Timeline
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
941 Railroad Avenue, VALLEJO, CA, 94592
DUNS: 079146294
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 George Martin
 (650) 369-4100
 gmartin@leclemens.com
Business Contact
 George Martin
Phone: (650) 369-4100
Email: gmartin@leclemens.com
Research Institution
N/A
Abstract
Radiotherapy, a key anticancer therapy, acts not only by killing cancer cells, but also by activating the body's immune system to attack the remaining cancer cells. However, the immune-stimulating effect is weakened by the tumor's capacity to reprogram immune cells, particularly macrophages, so that they instead actively promote tumor growth. RP-185 (Riptide Biosciences, Vallejo, CA),an engineered analog of a natural immunomodulatory peptide, has been shown to reverse this programming and restore the immune cells to tumor-Killing activity. This effect is additive to the T-cell sensitizing activity of checkpoint inhibitors, whose efficacy as an adjunct to radiotherapy is already being pursued in many clinical trials. we propose to confirm the efficacy and safety of RP-185 as a radiotherapy adjuvant, and establish optimum dosing schedules and concentrations preparatory to clinical trials.

* Information listed above is at the time of submission. *

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