Topic 374: Targeted and Sustained Release Microparticles for Colon Cancer Chemoprevention

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 75N91018C00035-0-0-0
Agency Tracking Number: N43CA180035
Amount: $299,810.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NCI
Solicitation Number: N/A
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
104 TW Alexander Dr, DURHAM, NC, 27709
DUNS: 080123728
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: Y
Principal Investigator
 Zhiguo (Jason) Zhou
 (336) 251-9219
Business Contact
 Zhiguo (Jason) Zhou
Phone: (336) 251-9219
Research Institution
Colorectal Cancer (CRC) is the third most common cancer both in men and women, as well as the second leading cause of cancer deaths with an estimated 135,430 new cases diagnosed and 50,260 deaths for 2017 in the United States. Given the limitations of screening tests and poor prognosis associated with advanced stage colorectal cancer, it would be of great interest in exploring chemoprevention strategies to reduce the incidence and mortality of this preventable malignancy. U.S. Preventive Services Task Force (USPSTF) has recommended routine aspirin use among those aged between 50 and 69 with specific cardiovascular risk profiles for CRC prevention. The widespread use of ASA solely for CRC prevention has been limited due to its systemic exposure and toxicity of routine use of immediate release (IR) aspirin tablets. It is worth mentioning that even enteric coated aspirin causes gastric side effects as plain (non-coated) ASA tablets do. Zymeron proposes to develop a targeted delivery approach which reduces the systemic exposure to ASA and increases its selective accumulation in target colon tissues as an effective strategy for more widespread use of ASA as a chemopreventive agent of CRC.

* Information listed above is at the time of submission. *

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