Topic 372: Highly multiplexed selection of aptamers to hundreds of canine immunotherapy targets

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 75N91018C00040-0-0-0
Agency Tracking Number: N43CA180040
Amount: $300,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NCI
Solicitation Number: N/A
Timeline
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
619 Broadway St., PEARLAND, TX, 77584
DUNS: 078474555
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 George Jackson
 (832) 230-5518
 bill.jackson@basepairbio.com
Business Contact
 George Jackson
Phone: (832) 230-5518
Email: bill.jackson@basepairbio.com
Research Institution
N/A
Abstract
The preclinical development of cancer therapeutics, including the recent trend and focus on cancer immunotherapies, is evolving from the traditional use of mouse models to the use of other animal models including canine, rat, and minipig. Each of these non-mouse models carries its own advantages and abilities to increase the clinical relevance of the model as compared to mouse models. Yet, the wide use of these models for preclinical validation of novel therapeutics is limited by multiple factors including the availability of analytically validated reagents, such as antibodies, and aptamers, for each model system. In this project, Base Pair Biotechnologies will use its patented process for highly multiplexed aptamer selection to rapidly generate at least 25 new affinity reagents in Phase I to important canine cancer markers. Our expert consultants in cancer immunology will aid in target selection along with our staff with extensive bioinformatics experience. These new reagents will be characterized for their equilibrium binding constants, their specificity, and demonstrated in two different assay formats - ELISA-like assays, and flow cytometry. In Phase II, we will use the same process to generate at least 100 more reagents and employed in additional applications relevant to cancer immunology studies and clinical trials.

* Information listed above is at the time of submission. *

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