Non-invasive cardiopulmonary monitor for mice

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$99,545.00
Award Year:
2004
Program:
SBIR
Phase:
Phase I
Contract:
1R43HL073573-01A1
Agency Tracking Number:
HL073573
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
EMPIRICAL TECHNOLOGIES CORPORATION
EMPIRICAL TECHNOLOGIES CORP., 3050-A BERKMAR DR, CHARLOTTESVILLE, VA, 22906
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
MARTIN BARUCH
(434) 296-7000
MCBARUCH@ADEPHIA.NET
Business Contact:
DAVID GERDT
(804) 296-7000
DAVIDETC@FIRSTVA.COM
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): The study of long-term variation in physiological cardiopulmonary rhythms in mice is rapidly expanding. The reason is that there are an ever-increasing number of strains of mice that have been genetically engineered to test scientific hypotheses about the molecular mechanisms of the cellular processes that control these biological rhythms. Since mice are so small, conventional recording systems need significant modification (indwelling vascular catheters) or are not applicable at all (skin electrodes). The development of a non-invasive sensor system for the continuous and reliable monitoring of respiratory rate, HR, and possibly blood pressure trends in mice is proposed. The sensor is based on a fiber-optic coupler sensor technology that has proven its applicability to physiological monitoring in humans in a number of applications. The sensor technology, which showed promising results in preliminary experiments, is very sensitive and scalable in size. The design of the sensor system, once it has been optimized using a "synthetic" mouse, will be tested on 8-10 mice that have been fitted with an EKG monitoring system commonly used in the mouse research community. The data will be analyzed and the reliability of the approach assessed using different algorithms, including wavelet transforms.

* information listed above is at the time of submission.

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