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Optimization of Ebola Virus Entry Inhibitors

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43AI138878-01
Agency Tracking Number: R43AI138878
Amount: $650,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIAID
Solicitation Number: PA17-302
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-03-01
Award End Date (Contract End Date): 2020-09-30
Small Business Information
San Diego, CA 92121-1341
United States
DUNS: 962535782
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (858) 766-0495
Business Contact
Phone: (858) 766-0495
Research Institution

Infection by several Ebola virus species is associated with severe viral hemorrhagic feverVHFin humansTo datesignificant Ebola virus outbreaks in central and western Africa have been associated with the EbolaZaireEBOVSudanSUDVand BundibugyoBDBVspecies with case fatality rates ranging fromDuring theEBOV outbreakpeople died from Ebola VHFGiven the lack of approved treatments and prophylacticsthe high mortality rate associated with infectionand the potential for geographical transplantation the development of broad spectrum Ebola virus antivirals for the treatment and prophylaxis of VHF remains an NIAID high priorityIn this proposal we detail plans to optimize an attractive hit to lead chemical series of Ebola virus cell entry inhibitors utilizing VSV pseudotype viruses expressing Ebola virus glycoproteins along with confirmatory BLSnative virus assays and initial vitro and in vivo ADMET studies to provide a lead compound compatible with oral administration for proof on concept studies in an in vivo animal efficacy model Several species of Ebolavirus are associated with severe hemorrhagic fevers exhibiting high fatality rates and are recognized as NIAID Category A high priority pathogensThe development of oral broad spectrum Ebolavirus antivirals could help to provide needed therapeutic treatments and prophylactics

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