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Development of an Accessible, High-Precision Histology Procurement System

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43GM130189-01
Agency Tracking Number: R43GM130189
Amount: $148,360.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: 400
Solicitation Number: PA17-302
Timeline
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-08-01
Award End Date (Contract End Date): 2020-01-30
Small Business Information
6273 WATERLOO DR
Easton, MD 21601-8575
United States
DUNS: 079401249
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 MICHAEL EMMERTBUCK
 (443) 226-5578
 memmertbuck@gmail.com
Business Contact
 LESLIE EMMERT-BUCK
Phone: (443) 226-5578
Email: memmertbuck@gmail.com
Research Institution
N/A
Abstract

Project Summary
Tissues contain multiple cell typesnervevasculatureepitheliumfibroblaststhat enable their specialized
physiological functionsQuantitative molecular analysis of cells from histological slides is useful in
developing a deeper understanding of fundamental pathophysiology and in generating effective clinical
interventionsSeveral strategies were developed in the past to more precisely recover cells from
heterogeneous tissue sectionsincluding manual razor scrapesmicromanipulatorsand laser
microdissection technologiesLaser dissection in particular has become an effective and established
methodwith several companies now offering high level instrumentation and accompanying
microgenomics assaysHoweverlaser dissection instruments alone are not sufficient to fully meet the
needs of the molecular pathology and biology fieldsWe recently invented a micropurification technology
that can recover specific cells or subcellular structures from histology slides within minutes and with
extreme precisionIf successfully optimized and validatedthe invention will expand the repertoire of tools
available to the researchmolecular pathology and oncology communitiesand enable experiments
requiring a level of precision that no current technology can accomplishThe two specific aims areAimOptimization of Cell and Nuclear EnrichmentAimAdvancement of mRNA and miRNA AnalysesProject Narrative
We recently invented a micropurification technology with the potential to recover specific cells or
subcellular structures from histology slides within minutes and with extreme precisionIf successfully
optimized and validatedthe invention will expand the repertoire of tools available to the researchmolecular pathology and oncology communitiesand enable experiments requiring a level of precision that
no current technology can accomplish

* Information listed above is at the time of submission. *

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