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Development of a protein drug for pancreatic cancer treatment

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 2R42CA217482-02
Agency Tracking Number: R42CA217482
Amount: $1,999,560.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: NCI
Solicitation Number: PA17-303
Timeline
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-09-26
Award End Date (Contract End Date): 2020-09-25
Small Business Information
5075 LAKE FJORD, Marietta, GA, 30068-1641
DUNS: 078411585
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 ZHIREN LIU
 (404) 413-5419
 zliu8@gsu.edu
Business Contact
 ZHIREN LIU
Phone: (404) 428-8540
Email: zliu8@gsu.edu
Research Institution
 GEORGIA STATE UNIVERSITY
 PO BOX 3999
ATLANTA, GA, 30302-3999
 Nonprofit college or university
Abstract
Abstract Pancreatic cancers are devastating diseases with five year survival rate less thanCurrentlythere is no effective treatment for advanced diseaseOne major barrier to efficacy of anti tumor therapeutics is the dense desmoplastic stromal responseEvidence suggests that cancer associated pancreatic stellate cellsCAPaSCproduce the stromal collagenThe ECM laid down by CAPaSC is considered to be one of the major contributors of resistance to established therapies of the diseasesDepleting CAPaSC and altering vessel density could significantly improve efficacy of existing pancreatic ductal adenocarcinomaPDACtreatmentsHowevercurrentlythere are no approved therapies that are able to deplete CAPaSCs in PDACWe have developed a novel therapeutic proteinProAgiousing rational protein designProAgio is designed to target integrinvat a novel sitenot the ligand binding siteProAgio specifically induces apoptosis of integrinvexpressing cells with high efficacy by a novel mechanism of drug actionrecruiting andampactivating caspaseat cytoplasmic domain ofWe reasoned thatsince both CAPaSC and angiogenic endothelial cells express high levels of integrinvand since ProAgio is very effective in inducing apoptosis of integrinvexpressing cellsProAgio should both deplete CAPaSC and eliminate new blood vessels in and around pancreatic tumorsThis unique strategy may prove advantageous in treatment of PDACOur STTR phase I studies demonstrated efficacy of ProAgio potentially as a PDAC treatment via various cancer modelsThe studies support our hypothesis that ProAgio can provide treatment benefit by simultaneously depleting the collagen producing CAPaSCs that support tumor desmoplasia and cancer cell growthwhile also eliminating newly grown cancer associated blood vessels that feed cancer cells and enable cancer metastasisData from our STTR phase I studies provides proof of principle for future clinical testsTo facilitate future clinical studies of ProAgio in PDAC patientswe propose toAimanalyze the pre clinical toxicologyTOXand pharmacokineticsPKof ProAgio with rats and monkeyTOX PK studies will enable IND application with US Food and Drug AdministrationFDAAimDetermine whether ProAgio can synergistically enhance treatment efficacy and delivery of immune checkpoint blockadesThis study will explore new therapeutic avenue for PDAC patients This research project develops and tests a novel protein agent for pancreatic cancer treatment

* Information listed above is at the time of submission. *

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