4D Acoustoelectric Cardiac Imaging for Fast and Accurate Mapping of Arrhythmias

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43HL144327-01
Agency Tracking Number: R43HL144327
Amount: $224,560.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NHLBI
Solicitation Number: PA17-302
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-09-21
Award End Date (Contract End Date): 2020-04-30
Small Business Information
1438 N CAMINO VILLA BONITA, Tucson, AZ, 85715-5101
DUNS: 080209753
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (520) 241-2719
Business Contact
Phone: (520) 345-0859
Email: sonia@cardiavue.com
Research Institution
Abstract Despite global success of interventional cardiac surgery for treatment of arrhythmiaselectroanatomical mappingEAMof the heart has significant drawbacksThe procedure is slow and prone to registration errorslargely ineffective for treating transient arrhythmiassuch as ventricular tachycardiaand exhibits relatively poor spatial resolutionWith only asuccess rate for first time interventionsthese limitations contribute to multiple erroneous ablationsrepeat proceduresand increased complications for the patientThis PhaseSBIR proposes to develop and validateD Acoustoelectric Cardiac ImagingACItechnology for mapping electrical current in the in vivo pig heartACI is a patented technology that offers real time capability and superior spatial resolutionandltmmfor rapid localization of arrhythmias during ablation therapyOur preliminary studies suggest that ACI would offer the following benefits over conventional EAMD real time imaging of current densities in the hearthigh spatial resolution determined by the US focusmmaccurate localization of both sustained and transient arrhythmiasfusion of current densitiesACIwith cardiac anatomy and motionpulse echo USThe primary goal of the PhaseSBIR is to demonstrate and validate ACI for in vivo mapping of the electrocardiogram and cardiac activation wave in the live pigThe project partners ElectroSonix LLC with The University of Arizona to enhance the ACI platform and assess performance for in vivo mapping of electrical current in a wild type pig modelOur ultimate vision is to develop a mobile or even portable platform based on proprietary ACI technologyi ehardwaresignal processingdata analysis and integrationfor fastreal time mapping of arrhythmias that is far superior to state of the art electrical cardiac mapping techniquesA successful demonstration in the pig heartPhasewould lead to an expanded Phaseproject directly comparing ACI with a commercial EAM systeme gGE CARTOfor image guided ablation during treatment of arrhythmiasThe overarching goal is to improve the success rate of resynchronization therapy and reduce chances of complication by limiting the number of unnecessary ablations and repeat proceduresThis would effectively reduce the chances for medical errors and improve the quality of life in patients who receive treatmentThe value from this SBIR will be the first step towards commercializing a fully integrated ACI medical device realization Project Narrative ElectroSonix LLC will partner with the University of Arizona to develop and validate acoustoelectric cardiac imagingACIa potentially revolutionary technology for high resolution and accurate electrical mapping of abnormal heart rhythms during ablation therapyThis technique has several advantages over current stateof the art imaging methods and could lead to higher success ratesfewer medical errors and complicationsand improved quality of life for patients who undergo corrective therapy for arrhythmias

* Information listed above is at the time of submission. *

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