HOLLOW-FIBER BIOREACTOR WITH IMPROVED OXYGENATION

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 11282
Amount: $49,845.00
Phase: Phase I
Program: SBIR
Awards Year: 1989
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
8500 Evergreen Blvd, Coon Rapids, MN, 55433
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
RECOMBINANT RESEARCH HAS FACILITATED THE IN VITRO PRODUCTIONOF MAMMALIAN CELL-SECRETED PRODUCTS. THESE PRODUCTS ARE USED IN THE IN VITRO AND IN VIVO DIAGNOSTIC AND THERAPEUTIC SETTING. PRODUCTS THAT HAVE BEEN APPROVED OR ARE IN THE APPROVAL PROCESS HAVE PROJECTED MARKET NEEDS ON THE ORDER OF100 KILOGRAMS PER YEAR, BUT LARGE QUANTITIES LIKE THIS WILL BE DIFFICULT TO PRODUCE USING TODAY'S STATE-OF-THE-ART CELL CULTURE METHODS. A NEW HOLLOW-FIBER BIOREACTOR HAS BEEN DEVELOPED THAT CAN MEET THESE PRODUCTION NEEDS IN A COST-EFFECTIVE MANNER. THE DEVICE HAS ALL OF THE ADVANTAGES OF HOLLOW-FIBER CELL CULTURE: HIGH CELL DENSITY, LOW CULTURE VOLUMES, HIGH PRODUCT CONCENTRATION AND PURITY, LOW SERUM/GROWTH FACTOR REQUIREMENT, AND COMPACT SIZE. THE BIOREACTOR IS A NOVEL DESIGN THAT IS EASILY MANUFACTURED WITHOUT LARGE INVESTMENTSIN CAPITAL EQUIPMENT AND IS LINEARLY SCALABLE. THE DEVICE CAN TRANSFER OXYGEN AT A RATE OF 196 MM/HOUR/LITER. THE PHASE I RESEARCH OBJECTIVE IS TO GENERATE THE DATA REQUIRED TO OPTIMIZE THE DESIGN OF THE COMMERCIAL BIOREACTOR. THIS BIOREACTOR WILL ALLOW VERY LARGE-SCALE MAMMALIAN CELL CULTURING WITH LESS SPACE AND REDUCED EQUIPMENT COSTS THAN CURRENT CELL CULTURE METHODS. THIS RESEARCH WILL LEAD TO PHASE II DEVELOPMENT OF THE BIOREACTORAND LAY THE GROUNDWORK FOR IMPROVED CELL-CULTURE INSTRUMENTATION DEVELOPMENT.

* Information listed above is at the time of submission. *

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