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Novel High Resolution Scintillator for Imaging Bone Microarchitecture in Flat Panel Cone Beam CT

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43AR073707-01
Agency Tracking Number: R43AR073707
Amount: $216,807.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIAMS
Solicitation Number: PA17-302
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-06-01
Award End Date (Contract End Date): 2019-05-31
Small Business Information
Watertown, MA 02472-4699
United States
DUNS: 073804411
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (781) 772-1741
Business Contact
Phone: (617) 668-6809
Research Institution

AbstractPathological changes in bone microarchitecture are associated with a broad range of
musculoskeletalMSKdiseasesincluding osteoporosisOPand osteoarthritisOAOP and OA carry
significant healthcare burdenwith an estimatedmillion US adults suffering from OP andmillion
afflicted by OAThis motivates quantitative assessment of bone microstructure on clinical imaging
systemsQuantitative metrics of bone microarchitecture remainhoweverunderutilized in OP and OA
because of limited spatial resolution of current orthopedic imaging modalitiesApplication of extremity
CBCT in quantitative imaging of bone microstructure is likely to have high impact in OA and OP becauseaOA occurs primarily in the extremitiesandbin OPmorphological measurements in distal extremities
were shown to be indicative of fracture riskincluding of hip fracturesAgainthe spatial resolution of
current extremity CBCTmmis insufficient to fully resolve themm trabeculaelimiting the
performance in assessment of bone qualityWe intend to address this specific issue through the
development of a novel sensor that promises to provide the necessary resolution without compromising
detector sensitivityEfficacy of such a detector will be demonstrated through CBCT scanning and
comparing results to those obtained using the current state of the art system Project NarrativeThe imaging platform resulting from integration of the proposed sensor into large area CMOS
readout will provide the unique ability to monitor bone microarchitecture in humans in vivo with sufficient
detection efficiency to support imaging in highly attenuating body sitesincluding major joints of the
extremitieship and spineFuture applications of this technology will extend beyond extremity CBCT toD andD fluoro visualization of stentsbreast CBCT for better visualization of micro calcificationsdentalmaxillofacial and ENT including temporal bone and inner middle ear imagingto name a few

* Information listed above is at the time of submission. *

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