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Targeting the sphingolipid pathway for the R&D of new antifungals

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R41AI134428-01A1
Agency Tracking Number: R41AI134428
Amount: $279,393.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIAID
Solicitation Number: PA17-303
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-08-01
Award End Date (Contract End Date): 2019-07-31
Small Business Information
86 DEER PARK RD, Dix Hills, NY, 11746-4900
DUNS: 080296540
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (631) 632-4024
Business Contact
Phone: (917) 833-0043
Research Institution
MORRISVILLE, NY, 13408-2608
 Domestic nonprofit research organization
ABSTRACT The goal of this project is to discover and develop a new therapeutic smore potent than current antifungals for the treatment of invasive fungal infectionsAmong invasive fungal infectionscryptococcosiscandidiasisand aspergillosis are the most life threateningThe incidence of these infections has risen more thanfold over the lastyearswith a mortality rate ofyearWe recently discovered a fungal enzymeceramide synthaseCeressential for fungal growth at neutralalkaline and acidic environmentsThusa fungal mutant lacking Ceris not pathogenic in animal models becauseupon infectionit cannot survive in host neutrallung and other organsalkalinebloodand acidicinflammatory tissueenvironmentsThusCeris an ideal target for the development of new antifungals because any compound blocking Cerwill be fungicidalWe have optimized a high throughput assay that allows the screen for selective and specific inhibitors of fungal CerThuswe will screen ChemBridge DIVERSet libraries for compounds inhibiting fungal Cerbut not human ceramide synthases and select potent hit molecule sto move forward for medicinal chemistry and preclinical studiesWe do have the experience and expertise to perform these studies NARRATIVE Fungal infections have dramatically increased during the last decade and new treatment strategies are neededThis proposal focuses on developing new compounds targeting the fungal but not the mammalian sphingolipid pathway

* Information listed above is at the time of submission. *

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