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Technology for Non-invasive High-throughput Breath Tracking in Rodents

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41HL142489-01
Agency Tracking Number: R41HL142489
Amount: $223,940.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NHLBI
Solicitation Number: PA17-303
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-06-01
Award End Date (Contract End Date): 2019-05-31
Small Business Information
Lexington, KY 40503-1229
United States
DUNS: 964938455
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (859) 257-2805
Business Contact
Phone: (650) 814-9918
Research Institution
LEXINGTON, KY 40526-0001
United States

 Nonprofit College or University

ABSTRACTSignal Solutions has developed a novelnoninvasive and automated piezoelectric based sleep
detection system for high throughput studies of sleep in miceand has recently expanded to rat studies as wellThe respiratory signal detected by the piezo sensor during sleep can be applied to investigate important health
conditions including respiratory depression due to disease or drug useand other sleep disordered breathing
conditions such as Central Sleep ApneaCSAwhich contributes to approximatelyof all sleep apnea in
humansRodent models are essential to better understand respiratory control of breathing and to investigate
respiratory abnormalities that present with diseaseCSA is increasingly recognized as an important
contributing factor to the morbidity and mortality in a number of cardiovascular diseasesRespiratory
depression can cause immediate death in diseases such as epilepsyand cases such as opiate overdoseor
many other drugsPreclinical studies of such drugs in rodents would be greatly improved if there was an easier
way to monitor breathingThe current methods used to monitor breathing in rodents are laboriousexpensiveand technically
challengingPlethysmography is used to study breathing in rodentsand measures small breath volumes while
the animal is confined to a small chamber This technology is expensive and stressful to the animaland can
only be used over short periodsSleep disordered breathing is difficult to examine due to time required for the
animal to adapt to the chamberand the limited time for keeping the animal confinedSignal Solutionssleep system is ideally suited to improve methods for assessing a variety of breathing
variablesDuring sleep or quiet wakebreathing is the primary movementand our technology thus provides
accurate respiratory tracesIn addition to breath ratesapneas are easily detectedand should be amenable
to automatic scoringThe advantages over current technology for detection of altered breathing includes costeffectivenoninvasivestress freecontinuous monitoring that is high throughputand requires no surgery to
monitor sleepAdapting our system for breathing applications will be made by meeting the following
objectivesOptimize compatibility of our piezo sensor system with standard plethysmographyCollect
simultaneous piezo and plethysmography data in both rats and mice under multiple conditionsScoreassess and quantify signals from the piezo system vsplethysmography for several respiratory variablesDevelop and optimize algorithms for automatic scoringand optimize performanceThe outcome of this project
will be to provide researchers with a simple to usecost effective technology for basic and pre clinical studies
in rodents investigating respiratory depressionsleep apneaand other disordered breathing during sleep that
contribute to extensive morbidity and mortality in people Project NarrativeOur goal is to develop simplerless expensive and less stressful
noninvasive technology to monitor breathing parameters in rodentsThis tool will
provide wider access to monitor respiratory output in rodents to study breathing
disorders associated with neurodegenerative diseasescentral sleep apneaheart
failurespinal cord injury and drugs with dangerous respiratory related side effects

* Information listed above is at the time of submission. *

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