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Dynamically softening implantable microelectrode arrays

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43MH118180-01A1
Agency Tracking Number: R43MH118180
Amount: $182,682.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: 101
Solicitation Number: PA17-302
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-06-01
Award End Date (Contract End Date): 2019-05-31
Small Business Information
Dallas, TX 75252-8004
United States
DUNS: 080158943
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (972) 861-2420
Business Contact
Phone: (972) 861-2420
Research Institution

Project summary
We propose to demonstrate the feasibility of softening multi shank microelectrode arrays which are stiff during
insertion and soft during chronic useTo dateno one has demonstrated aD softening electrode arrayCurrent technologiesmade from silicon can be miniaturehigh densitybatch fabricated and capable of
supporting active on board electronicsSiliconhoweveris a brittle materialand while its stiffness allows for
easy implant into soft neural tissueit presents a serious mechanical mismatch between the implanted device
and the soft neural tissue after implantOther current penetrating flexible electronics technologies have been
limited toD structuresIn this Phase I SBIR proposalQualia Incwill explore the feasibility of adapting its planar processing thin film
photolithography technologies into a third dimensionPrevious SBIR funding from DARPA helped establish our
shape memory polymerSMPsubstrates as candidates for chronically viable neural implantsHoweverour
past studies have been limited toD devicesIn this proposalwhich is focused on innovative packaging
technologieswe aim to createD architectures which fill a critical void in the neuroscience research
community Project Narrative
A central goal of contemporary neuroscience is to understand the relationships between the functional
connectivity map of neuronal circuits and their physiological or pathological functionsCurrent multi shank
microelectrode arraysthe tools used to assess these phenomenaare not chronically stable limiting their
clinical efficacyQualia Incproposes a softeningD multi shank electrode technology that could extend the
lifetime and increase the performance of implantable bioelectronics

* Information listed above is at the time of submission. *

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