The objective of this contract is to develop an HIV latent reservoir assay using a microwell array consumable.

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 272201800032C-0-0-0
Agency Tracking Number: N43AI180032
Amount: $283,407.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIAID
Solicitation Number: N/A
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
PO Box 13169, RESEARCH TRIANGLE PARK, NC, 27709-0003
DUNS: 962655853
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: Unavailable
Principal Investigator
 Steven Gebhart
 (919) 608-2035
Business Contact
 Steven Gebhart
Phone: (919) 608-2035
Research Institution
A critical remaining challenge toward a true cure for HIV is understanding how latently infected cells evade the immune system and persist as lifelong viral reservoirsOne eradication strategythe so calledshock and killapproachrelies on cell activating compounds to reverse latent infectionand subsequent antiretroviral therapy to eradicate newly activated cellsHoweverthese compounds activate only a minority of latently infected cellsimplying a complex interplay of epigenetic control points and stochastic cell fate determinationDetecting latency reversal therefore requires time consuming phenotypic assays to identify those rare cells displaying newly formed viral infectionTo detect such eventsthe single cell immunology field has put forth a number of assaysbut these are incapable of pairing phenotypic latency reversal with downstream molecular analysesAn urgent need therefore exists for a scalable single cell assay to detect the latent reservoirThe utility of such an assay would serve several roles in contemporary HIV cure researchendpoint analysis of the latent reservoir in clinical trialsa research tool to investigate the molecular precursors of both latency reversal and resistance anda companion diagnostic for HIV therapeutics aimed at eliminating the latent reservoirthereby curing HIV infection

* Information listed above is at the time of submission. *

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