Discovery of new small molecule TLR4 agonists for the treatment of allergic rhinitis

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 272201800036C-0-0-0
Agency Tracking Number: N43AI180036
Amount: $592,624.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIAID
Solicitation Number: N/A
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
DUNS: 080350279
HUBZone Owned: N
Woman Owned: Unavailable
Socially and Economically Disadvantaged: N
Principal Investigator
 Juhienah Khalaf
 (406) 361-1672
Business Contact
 Juhienah Khalaf
Phone: (406) 361-1672
Research Institution
The long term goal of this proposal is the development of an intranasal stand alone TLRagonist to treat allergic rhinitisUnlike antigen specific therapythis allergen independent approach will be broadly applicable to a vast array of allergens patients are exposed toSuch treatment would provide relief within hours of administrationproviding short term symptom controland has the potential to deliver long term disease remission via allergen dependent T cell and B cell memory responsesThe first objective of this proposal is to identify new small molecule TLRagonists via high throughput virtual screening of a large library of commercially available compounds using known TLRMDcrystal structuresThe second objective is to confirm human and murine TLRactivity of the hits using HEKTLRcell lines and evaluate a selected set of hTLRagonists for cytokine inductioncytotoxicity and ILinhibition in PBMCAfter lead optimization in Objectivetwo leads will be evaluated in Objectivefor their ability to modulate Thallergic response in an established mouse model of acute allergic pulmonary inflammationThe innovation of this proposal lies in using high throughput virtual screening to identify new small molecule TLRagonistsand the use of nonLPS likeTLRagonists for the treatment of allergy

* Information listed above is at the time of submission. *

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