SBIR Phase I: Single-molecule field-effect transistor arrays for multiplexed genomic identification of infectious diseases

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 1843244
Agency Tracking Number: 1843244
Amount: $225,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: BT
Solicitation Number: N/A
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-02-01
Award End Date (Contract End Date): 2020-01-31
Small Business Information
180 VARICK ST RM 526, NEW YORK, NY, 10014
DUNS: 081250499
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Steven Warren
 (914) 393-2633
 swarren@quicksilverbiosciences.com
Business Contact
 Inanc Meric
Phone: (917) 345-6424
Email: inancmeric@quicksilverbiosciences.com
Research Institution
N/A
Abstract
The broader impact/commercial potential of this Small Business Innovation Research Project (SBIR) project is the development of a platform for pathogen identification and other genomic applications that achieves rapid, sensitive, multiplexed single-molecule detection. The genomic diagnostics market is poised to grow to $40 billion by 2021. The goal of this platform will be to offer multiplexed detection of more than 1,000 pathogens, allowing accurate point-of-care diagnosis of infectious diseases. Other genomic applications that also are possible include assessment of the microbiome or monitoring opportunistic infections in pulmonary diseases. In addition, the platform has the potential for use in genomic sequencing, a market that is expected to reach $9 billion by 2020. The intellectual merit of this SBIR Phase I project is to develop a highly multiplexed, bioelectronic, label-free assay platform capable of real-time, label-free detection of thousands of nucleic acid targets without amplification. This will be accomplished through the use of nanoscale single-molecule field-effect transistors (smFETs) on a complementary metal-oxide semiconductor (CMOS) integrated-circuit platform, which fully leverages the economies of scale of modern semiconductor manufacturing. The initial target application for this technology is multiplexed pathogen identification at the point-of-need. This project will bring the technology to wafer-scale manufacturing, which will both improve device quality and lower the per device cost of manufacture, and demonstrate proof-of-concept for genomic detection (without amplification) on clinical samples. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

* Information listed above is at the time of submission. *

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