SBIR Phase I:De Novo Design of Unnatural Peptides - Affordable Drug Discovery Platform

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 1013428
Agency Tracking Number: 1013428
Amount: $150,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solicitation Year: 2010
Solicitation Topic Code: BC
Solicitation Number: NSF 09-609
Small Business Information
671 S. Willow Garden Dr., Lehi, UT, 84043
DUNS: 607333569
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Przemyslaw Czyryca
 (435) 757-4173
Business Contact
 Przemyslaw Czyryca
Title: MBA
Phone: (435) 757-4173
Research Institution
This Small Business Innovation Research (SBIR) Phase I project involves testing and validation of a novel drug discovery platform. An original algorithm is used to design previously unknown peptides that are capable of modulating selected macromolecules of therapeutic importance. Then, such designer peptides are routinely and inexpensively synthesized. The utilization of unusual amino acids is prioritized in the presented approach, to improve the pharmacological properties of the designed peptides. In the proposed study, the design of compounds disrupting the function of selected viral envelope proteins will be attempted. The broader/commercial impacts of this research result from its low costs. De novo design of heavily modified peptides offers a promise of an attractive, affordable drug discovery platform, especially suitable to targeting biomedical problems that are currently neglected, due to the high cost of the competing, currently predominant high throughput screening (HTS) approach to discovering small molecule drugs. Examples include medical conditions characteristic to poorer regions of the world, or rare conditions, which may nevertheless prove important in the context of biodefense. These two areas often overlap. Such medical conditions usually offer a too low financial incentive to justify HTS-based research, yet the effort can be made profitable (in addition to social benefits) if it is based on a changed, less costly discovery paradigm.

* Information listed above is at the time of submission. *

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