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Fast and Flexible Differential Equation Model Fitting with Application to Pharmacometrics

Award Information
Agency: Department of Defense
Branch: Navy
Contract: N68335-18-C-0110
Agency Tracking Number: N16A-016-0045
Amount: $999,034.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: N16A-T016
Solicitation Number: 2016.0
Timeline
Solicitation Year: 2016
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-11-15
Award End Date (Contract End Date): 2019-11-14
Small Business Information
2 Tunxis Road
Tariffville, CT 06081
United States
DUNS: 146497263
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 William Gillespie
 (919) 371-2786
 billg@metrumrg.com
Business Contact
 Marc Gastonguay
Phone: (860) 735-7043
Email: marcg@metrumrg.com
Research Institution
 Columbia University
 Heather Horgan
 
615 West 131st Street Room 254, Mail Code 8725
New York, NY 10027-7922
United States

 (212) 854-6851
 Nonprofit college or university
Abstract

We are developing a platform for pharmacometric data analysis workflow that is much more flexible and efficient than anything else on the market. This will be accomplished by (1) developing new functions within Stan, a widely used, open-source, probabilistic programming language and Bayesian inference engine, for computationally efficient data analysis using complex differential equation models, (2) developing new inference engines for rapid approximate Bayesian analysis, (3) developing new software tools for pharmacometric data manage- ment, visualization of modeling results, and report generation, and (4) integrating these components with Metrums commercial METWORX platform that allows for on-demand, auto- scaling, distributed cloud computing in a regulatory compliant workflow.

* Information listed above is at the time of submission. *

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