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Host-Targeted Antiviral Drugs Providing Rapid, Scalable, Stable, Broad-Spectrum MedicalCountermeasure Against Marburg Virus

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911QY-18-P-0300
Agency Tracking Number: C18A-002-0008
Amount: $149,997.49
Phase: Phase I
Program: STTR
Solicitation Topic Code: CBD18A-002
Solicitation Number: 2018.0
Timeline
Solicitation Year: 2018
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-09-25
Award End Date (Contract End Date): 2019-03-25
Small Business Information
3805 Old Easton Rd
Doylestown, PA 18902
United States
DUNS: 078290773
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Stacy Remiszewski
 (201) 639-4340
 stacy@forgelifescience.com
Business Contact
 Lillian Chiang
Phone: (267) 893-6755
Email: lillian@forgelifescience.com
Research Institution
 Baruch S. Blumberg Institute
 Nancy Young
 
3805 Old Easton Road
Doylestown, PA 18902
United States

 (267) 370-5219
 Domestic nonprofit research organization
Abstract

In a pandemic or exposure to weaponized Marburg virus the morbidity, mortality and social unrest that will ensue before vaccines orMilitary operating on foreign soil as well as to the population of the US Homeland. Practically all threat agents of biological origin (except forcertain non-proteinaceous toxins, typically produced by marine organisms and fungi) have their structure and vital function intimatelyintertwined with highly characteristic protein molecules. Detection and characterization of these signature protein molecules can provide anextremely accurate approach to the detection of the threat agents. We propose to develop, prototype and validate a field-portable massspectrometer with associated disposable cartridges for biothreat agents. The system will be capable of detecting all classes of biothreat agentsin cluttered sample matrices. The disposable cartridge will be used to prepare the sample for analysis in the spectrometer. The system isanticipated to have an analysis time of less than 5 minutes and will have a cost per sample of less than $20.

* Information listed above is at the time of submission. *

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