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INSPIRE - In-Mask Sensors for Physiological Investigation of Respiratory Exhalation

Award Information
Agency: Department of Defense
Branch: Defense Health Program
Contract: W81XWH-18-C-0310
Agency Tracking Number: H2-0283
Amount: $999,942.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: DHP16C-002
Solicitation Number: 16.C
Timeline
Solicitation Year: 2016
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-04-30
Award End Date (Contract End Date): 2020-09-29
Small Business Information
1585 Marauder St., Chico, CA, 95973
DUNS: 933302655
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Susana Carranza
 Senior Chemical Engineer
 (512) 589-0718
 scarranza@makelengineering.com
Business Contact
 Dr. Darby B. Makel
Phone: (530) 895-2771
Email: dmakel@makelengineering.com
Research Institution
 Sandia National Laboratories
 Anup K. Singh Anup K. Singh
 1515 Eubank SE
Array
Albuquerque, NM, 87123
 (925) 294-1260
 Federally funded R&D center (FFRDC)
Abstract
Makel Engineering, Inc. and Sandia National Laboratories propose to demonstrate an advanced multi-modal sensor system for in-situ analysis of exhaled volatile organic compounds (VOCs) for pilots, divers and field patients. The In-Mask Sensors for Physiological Investigation of Respiratory Exhalation – INSPIRE combines a micro-gas chromatograph (?GC) and miniature ion mobility spectrometer (IMS) for detection of trace amounts of exhaled breath VOCs with miniature solid state sensors for inorganic compounds found in breath such as oxygen, carbon dioxide, moisture and the inert gases nitrogen, argon and helium. In Phase I, conventional sampling and GC columns were coupled with miniature low temperature co-fired ceramic (LTCC) based IMS to demonstrate detection of the VOCs in EPA TO-15 method. In Phase II the sampling and GC columns will be replaced with a micro-preconcentrator and a micro-GC column, integrated with the LTCC IMS and solid state sensors for inorganic compounds detection. The highly compact INSPIRE will be suitable for integration with a respirator mask, enabling breath analysis on the field to monitor physiological condition and in turn enable adjusting operational conditions to prevent conditions such as pulmonary oxygen toxicity (PO2T) due to use of supplemental oxygen, improving determination of oxygen exposure limits in all populations.

* Information listed above is at the time of submission. *

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