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Developing Software for Pharmacodynamics and Bioassay Studies

Award Information
Agency: Department of Defense
Branch: Defense Health Program
Contract: W81XWH18C0152
Agency Tracking Number: H2-0307
Amount: $999,975.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: DHP16C-001
Solicitation Number: 2016.0
Timeline
Solicitation Year: 2016
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-10-01
Award End Date (Contract End Date): 2021-02-23
Small Business Information
7926 Jones Branch Drive,, mclean, VA, 22102
DUNS: 001899546
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: Y
Principal Investigator
 Hua Liang
 (202) 994-7844
 hliang@email.gwu.edu
Business Contact
 Larry Liu
Phone: (703) 348-8284
Email: larry.liu@tconnex.com
Research Institution
 George Washington Universtiy
 Rebekka Egger
 2121 I Street N.W.
Washington DC, VA, 20052
 (202) 994-7322
 Domestic nonprofit research organization
Abstract
The goal is to develop a software tool that implements a novel approach applicable to fit general pharmacologic, toxicology, or other biomedical data, that may exhibit a non-monotonic dose-response relationship for which the current parametric models fail.The software explores dose-response relationships using both monotonic and non-monotonic models, and estimates the associated dose-response curves, which can further be used to obtain various important parameters such as IC50, EC50, ED50, LD50, Km, Vmax, and AUC. The tool can be used for hormesis dose response curves. In toxicology, hormesis is a special dose response feature characterized by low dose stimulation and high dose inhibition. Furthermore, the tool can model U-shaped dose response relationships frequently observed in toxicology and epidemiology studies.

* Information listed above is at the time of submission. *

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