Freeze Dried Plasma for Canines

Hemorrhage is the leading cause of preventable death in combat, and damage control resuscitation (DCR) research has shown that plasma is a superior resuscitation fluid for severely injured, bleeding canine casualties.However, cold chain requirements make managing fresh frozen plasma (FFP) supply logistics difficult in austere environments.Limited supplies of pathogen reduced freeze-dried plasma (FDP) are currently available to the US military today through an agreement with the French Military for human use.However, there is no capability to provide Military Working Dogs (MWD) with any blood products. In this Phase II SBIR, Mantel Technologies proposes to continue the development of an FDP process and packaging solution for military working dogs and other canines. This effort will expand upon Phase I data to broaden repeatability, assess safety via a low risk study, and develop a user-focused canine FDP kit for field use.