Enhanced Canine Performance, Protection and Survivability

Award Information
Agency: Department of Defense
Branch: Special Operations Command
Contract: H9240519C0005
Agency Tracking Number: S2-0437
Amount: $1,752,422.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: SOCOM172-002
Solicitation Number: 2017.2
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-12-10
Award End Date (Contract End Date): 2020-12-09
Small Business Information
27 Strathmore Road, Natick, MA, 01760
DUNS: 080189823
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Kim Vandegriff
 (858) 583-1223
Business Contact
 Joseph Tucker
Phone: (508) 627-0485
Email: joe.tucker@virtechbio.com
Research Institution
Currently, there is no resuscitation fluid with oxygen carrier and plasma expansion capabilities to treat hemorrhagic shock in combat canines. Under SOCOM SBIR Phase 1, VirTech Bio developed a new hemoglobin-based oxygen carrier, VIR-VET, and performed successful feasibility safety and efficacy tests in rat models. In those studies, VIR-VET demonstrated prolonged vascular retention, without adverse hemodynamic effects, and longer survival times in a hemorrhagic shock model. In Phase 2, Technical Issues will be addressed under four Tasks: 1) Finalize processing of the prototype VIR-VET to be used for stability studies in accordance with FDA guidelines and for use in pre-clinical tests. 2) Acute toxicity studies will be performed in vivo in canines. 3) Experimental mechanism of action studies, based on preliminary Phase 1 studies in rats, will be assessed in a PK study to evaluate circulating half-life in canines and a hemorrhage and resuscitation model in canines using the pre-clinical grade material. Efficacy will be evaluated in canines through measures of oxygen transport and survivability in the hemorrhagic shock model. The hemorrhagic shock model is designed to mimic battlefield treatment of canine hemorrhage before hospital care is available.

* Information listed above is at the time of submission. *

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