TECHNICAL FEASIBILITY DEVELOPING A RECEPTOR TEST FOR A MODEL BIOLOGICAL TOXIN

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$46,938.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
5812
Agency Tracking Number:
5812
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2990 Anthony Rd, Burlington, NC, 27215
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DR R KEVIN PEGG
(919) 226-6311
Business Contact:
() -
Research Institution:
n/a
Abstract
ENVIRONMENTAL DIAGNOSTICS, INC. PROPOSED TO DETERMINE THE FEASIBILITY OF APPLYING ITS NEW INNOVATIVE HAPTEN TECHNOLOGY TO THE DEVELOPMENT OF IMMUNORECEPTORS FOR DETECTION AND ASSAY OF BIOLOGICAL TOXINS. THE NEW HAPTEN RECEPTOR TECHNOLOGY OVERCOMES PREVIOUS SCIENTIFIC LIMITATIONS AND TECHNICAL DIFFICULTIES IN DEVELOPING IMMUNOASSAYS FOR HIGHLYTOXIC, LOW MOLECULAR WEIGHT PROTEIN TOXINS. TO DATE, THE TECHNOLOGY HAS BEEN USED TO DEVELOP TESTS FOR THE TOXIC CHEMICALS DIOXIN, POLY CHLORINATED BIPHENYLS AND ETHYLENE DIBROMIDE WITH SENSITIVITIES OF 10 PARTS PER TRILLION. IMMUNOASSAYS MAY BE ENGINEERED TO DEVELOP TESTS WHICH ARE HIGHLY SPECIFIC FOR A PARTICULAR TOXIN, OR FOR A FAMILY OF CHEMICALLY RELATED TOXINS, OR FOR A PARTICULAR TOXIN AND ITS METABOLITES AND ANALOGS. TETRODOTOXIN WILL BE USED AS A MODEL BIOLOGICAL TOXIN IN PHASE I. THE IMMUNORECEPTORS FOR TETRODOTOXIN WILL BE ADAPTED TO THE COMPANY'S EZ-SCREEN WHICH IS A LOW COST, COMMERCIALLY SUCCESSFUL FIELD TEST THAT CAN DETECT TOXIC CHEMICALS IN THE PARTS PER TRILLION RANGE WITHOUT INSTRUMENTATION. A COLOR CHANGE RESULTS IN 3 TO 5 MINUTES THAT CAN BE EASILY INTERPRETED BY A RELATIVELY UNSKILLED WORKER. SUCCESS IN PHASE I WILL INDICATE THAT TESTS CAN BE QUICKLY DEVELOPED IN PHASE II FOR 15 OR MORE BIOLOGICAL TOXINS.

* information listed above is at the time of submission.

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