BIOTINYLATED DNA PROBE FOR THE DIAGNOSIS OF CERVICAL CARCINO

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 3045
Amount: $368,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1988
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
325 Hudson St., New York, NY, 10013
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Hueylang Yang
 Principal Investigator
 (212) 741-3838
Business Contact
Phone: () -
Research Institution
N/A
Abstract
HUMAN PAPILLOMA VIRUS (HPV) INFECTIONS ARE A COMMON FORM OF SEXUALLY TRANSMITTED DISEASE. INFECTIONS WITH TWO STRAINS OF HPV, HPV-16 AND HPV-18, HAVE BEEN CORRELATED WITH CERVICAL CARCINOMA. DNA FROM THESE VIRUSES HAS BEEN DETECTED IN TUMOR TISSUE FROM PATIENTS WITH THIS MALIGNANCY. IN PHASE I OF THIS STUDY, WE WILL IDENTIFY AND ISOLATE REGIONS OF THE HPV-16 AND HPV-18 GENOMES THAT CAN SPECIFICALLY RECOGNIZE THESE VIRUSES IN CERVICAL CARCINOMA SAMPLES. THESE HPV-SPECIFIC DNA PROBES WILL PROVIDE THE BASIS FOR PHASE II STUDIES, WHERE WE WILL DEVELOP RAPID, SENSITIVE, SPECIFIC, AND SIMPLE NONRADIOACTIVE ASSAYS FOR THE DETECTION OF HPV-16 AND HPV-18 DNA DIRECTLY IN TISSUE SAMPLES TAKEN FROM PATIENTS WITH EITHER PAPILLARY WARTS OR CERVICAL CARCINOMA. THIS DNA-BASED DIAGNOSTIC SYSTEM WILL GREATLY FACILITATE THE EARLY DETECTION, DIAGNOSIS, AND TREATMENT OF PATIENTS WITH GENITAL HPV INFECTIONS. IT MAY ALSO PROVIDE THE BASIS FOR THE DEVELOPMENT OF A COMMERCIALLY RELEVANT ASSAY FOR DETECTING THE OCCURRENCE OR THE RECURRENCE OF CERVICAL CARCINOMA AT AN EARLY STAGE OF THE DISEASE.

* Information listed above is at the time of submission. *

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