BIOTINYLATED DNA PROBE FOR THE DIAGNOSIS OF CERVICAL CARCINO

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$368,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
3045
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Enzo Biochem Inc.
325 Hudson St., New York, NY, 10013
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Hueylang Yang
Principal Investigator
(212) 741-3838
Business Contact:
() -
Research Institution:
n/a
Abstract
HUMAN PAPILLOMA VIRUS (HPV) INFECTIONS ARE A COMMON FORM OF SEXUALLY TRANSMITTED DISEASE. INFECTIONS WITH TWO STRAINS OF HPV, HPV-16 AND HPV-18, HAVE BEEN CORRELATED WITH CERVICAL CARCINOMA. DNA FROM THESE VIRUSES HAS BEEN DETECTED IN TUMOR TISSUE FROM PATIENTS WITH THIS MALIGNANCY. IN PHASE I OF THIS STUDY, WE WILL IDENTIFY AND ISOLATE REGIONS OF THE HPV-16 AND HPV-18 GENOMES THAT CAN SPECIFICALLY RECOGNIZE THESE VIRUSES IN CERVICAL CARCINOMA SAMPLES. THESE HPV-SPECIFIC DNA PROBES WILL PROVIDE THE BASIS FOR PHASE II STUDIES, WHERE WE WILL DEVELOP RAPID, SENSITIVE, SPECIFIC, AND SIMPLE NONRADIOACTIVE ASSAYS FOR THE DETECTION OF HPV-16 AND HPV-18 DNA DIRECTLY IN TISSUE SAMPLES TAKEN FROM PATIENTS WITH EITHER PAPILLARY WARTS OR CERVICAL CARCINOMA. THIS DNA-BASED DIAGNOSTIC SYSTEM WILL GREATLY FACILITATE THE EARLY DETECTION, DIAGNOSIS, AND TREATMENT OF PATIENTS WITH GENITAL HPV INFECTIONS. IT MAY ALSO PROVIDE THE BASIS FOR THE DEVELOPMENT OF A COMMERCIALLY RELEVANT ASSAY FOR DETECTING THE OCCURRENCE OR THE RECURRENCE OF CERVICAL CARCINOMA AT AN EARLY STAGE OF THE DISEASE.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government