BIOTINYLATED DNA PROBE FOR THE DIAGNOSIS OF CERVICAL CARCINO

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$368,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
3045
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Enzo Biochem Inc.
325 Hudson St., New York, NY, 10013
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Hueylang Yang
Principal Investigator
(212) 741-3838
Business Contact:
() -
Research Institution:
n/a
Abstract
HUMAN PAPILLOMA VIRUS (HPV) INFECTIONS ARE A COMMON FORM OF SEXUALLY TRANSMITTED DISEASE. INFECTIONS WITH TWO STRAINS OF HPV, HPV-16 AND HPV-18, HAVE BEEN CORRELATED WITH CERVICAL CARCINOMA. DNA FROM THESE VIRUSES HAS BEEN DETECTED IN TUMOR TISSUE FROM PATIENTS WITH THIS MALIGNANCY. IN PHASE I OF THIS STUDY, WE WILL IDENTIFY AND ISOLATE REGIONS OF THE HPV-16 AND HPV-18 GENOMES THAT CAN SPECIFICALLY RECOGNIZE THESE VIRUSES IN CERVICAL CARCINOMA SAMPLES. THESE HPV-SPECIFIC DNA PROBES WILL PROVIDE THE BASIS FOR PHASE II STUDIES, WHERE WE WILL DEVELOP RAPID, SENSITIVE, SPECIFIC, AND SIMPLE NONRADIOACTIVE ASSAYS FOR THE DETECTION OF HPV-16 AND HPV-18 DNA DIRECTLY IN TISSUE SAMPLES TAKEN FROM PATIENTS WITH EITHER PAPILLARY WARTS OR CERVICAL CARCINOMA. THIS DNA-BASED DIAGNOSTIC SYSTEM WILL GREATLY FACILITATE THE EARLY DETECTION, DIAGNOSIS, AND TREATMENT OF PATIENTS WITH GENITAL HPV INFECTIONS. IT MAY ALSO PROVIDE THE BASIS FOR THE DEVELOPMENT OF A COMMERCIALLY RELEVANT ASSAY FOR DETECTING THE OCCURRENCE OR THE RECURRENCE OF CERVICAL CARCINOMA AT AN EARLY STAGE OF THE DISEASE.

* information listed above is at the time of submission.

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