CYANIDE IS A RAPIDLY ACTING POISON THAT AFFECTS RESPIRATION IN BIOLOGICAL SYSTEMS.

Award Information
Agency: Department of Defense
Branch: Army
Contract: N/A
Agency Tracking Number: 1939
Amount: $78,625.00
Phase: Phase I
Program: SBIR
Awards Year: 1985
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
300c Corporate Ct, South Plainfield, NJ, 07080
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 FRANK F DAVIS
 (201) 668-1800
Business Contact
Phone: () -
Research Institution
N/A
Abstract
CYANIDE IS A RAPIDLY ACTING POISON THAT AFFECTS RESPIRATION IN BIOLOGICAL SYSTEMS. VICTIMS MAY DIE IN MINUTES. ENZON, INC. IS THE EXCLUSIVE LICENSEE FOR A PATENTED PROCESS FOR THE CHEMICAL MODIFICATION OF ENZYMES THAT GREATLY EXTEND THEIR BLOOD CIRCULATING LIFE, ELIMINATES OR MINIMIZES IMMUNOGENICITY, AND INCREASES STABILITY. ENZYMES THUS MODIFIED ("PEG-ENZYMES") ARE EFFECTIVE THERAPEUTIC AGENTS. RHODANESE IS AN ENZYME THAT DETOXIFIES CYANIDE. ENZON WILL PREPARE PEG-RHODANESE AND EVALUATE IT FOR THERAPEUTIC EFFECTIVENESS AGAINST CYANIDE POISONING IN MICE. THE OBJECT IS TO DEVELOP A THERAPY THAT IS FAR SUPERIOR TO THOSE CURRENTLY AVAILABLE. IN ADDITION, THE PROPHYLACTIC EFFECTIVENESS OF PEG-RHODANESE WILL BE EVALUATED. THE GREATLY EXTENDED BLOOD LIFE OF PEG-RHODANESE SHOULD MAKE IT EFFECTIVE EVEN WHEN INJECTED SEVERAL HOURS PRIOR TO CYANIDE ADMINISTRATION. THE RESEARCH AND DEVELOPMENT WILL FEATURE (A) THE PURIFICATION OF RHODANESE; (B) ITS CHEMICAL MODIFICATION TO PRODUCE PEG-RHODANESE; (C) AN EVALUATION OF THE ACTIVITY, STABILITY, BLOOD CIRCULATING LIFE, AND IMMUNOGENICITY OF PEG-RHODANESE, AND (D) EVALUATION OF PEGRHODANESE'S THERAPEUTIC AND PROPHYLACTIC EFFECTIVENESS.

* Information listed above is at the time of submission. *

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