CYANIDE IS A RAPIDLY ACTING POISON THAT AFFECTS RESPIRATION IN BIOLOGICAL SYSTEMS.

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$78,625.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
1939
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Enzon Inc
300c Corporate Ct, South Plainfield, NJ, 07080
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
FRANK F DAVIS
(201) 668-1800
Business Contact:
() -
Research Institution:
n/a
Abstract
CYANIDE IS A RAPIDLY ACTING POISON THAT AFFECTS RESPIRATION IN BIOLOGICAL SYSTEMS. VICTIMS MAY DIE IN MINUTES. ENZON, INC. IS THE EXCLUSIVE LICENSEE FOR A PATENTED PROCESS FOR THE CHEMICAL MODIFICATION OF ENZYMES THAT GREATLY EXTEND THEIR BLOOD CIRCULATING LIFE, ELIMINATES OR MINIMIZES IMMUNOGENICITY, AND INCREASES STABILITY. ENZYMES THUS MODIFIED ("PEG-ENZYMES") ARE EFFECTIVE THERAPEUTIC AGENTS. RHODANESE IS AN ENZYME THAT DETOXIFIES CYANIDE. ENZON WILL PREPARE PEG-RHODANESE AND EVALUATE IT FOR THERAPEUTIC EFFECTIVENESS AGAINST CYANIDE POISONING IN MICE. THE OBJECT IS TO DEVELOP A THERAPY THAT IS FAR SUPERIOR TO THOSE CURRENTLY AVAILABLE. IN ADDITION, THE PROPHYLACTIC EFFECTIVENESS OF PEG-RHODANESE WILL BE EVALUATED. THE GREATLY EXTENDED BLOOD LIFE OF PEG-RHODANESE SHOULD MAKE IT EFFECTIVE EVEN WHEN INJECTED SEVERAL HOURS PRIOR TO CYANIDE ADMINISTRATION. THE RESEARCH AND DEVELOPMENT WILL FEATURE (A) THE PURIFICATION OF RHODANESE; (B) ITS CHEMICAL MODIFICATION TO PRODUCE PEG-RHODANESE; (C) AN EVALUATION OF THE ACTIVITY, STABILITY, BLOOD CIRCULATING LIFE, AND IMMUNOGENICITY OF PEG-RHODANESE, AND (D) EVALUATION OF PEGRHODANESE'S THERAPEUTIC AND PROPHYLACTIC EFFECTIVENESS.

* information listed above is at the time of submission.

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