THE LONG-TERM GOAL OF THIS PROJECT IS TO DEVELOP A THERA- PEUTIC URICASE THAT CAN BE USED IN HYPERURICEMIA AND THE VARIOUS MANIFESTATIONS OF GOUT, INCLUDING ACUTE AND CHRONIC GOUTY ARTHRITIS TOPHI AND URATE DEPOSITS IN TISSUES AND ORGANS, AND URIC ACID

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4878
Amount: $43,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Enzon Inc
Middlesex Business Center, 300-c Corporate Court, South Plainfield, NJ, 07080
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 ABRAHAM ABUCHOWSKI
 PRINCIPAL INVESTIGATOR
 (201) 668-1800
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE LONG-TERM GOAL OF THIS PROJECT IS TO DEVELOP A THERA- PEUTIC URICASE THAT CAN BE USED IN HYPERURICEMIA AND THE VARIOUS MANIFESTATIONS OF GOUT, INCLUDING ACUTE AND CHRONIC GOUTY ARTHRITIS TOPHI AND URATE DEPOSITS IN TISSUES AND ORGANS, AND URIC ACID NEPHROPATHY. IT IS EXPECTED THAT THE THERAPEUTIC URICASE WILL BE ABLE TO COMPLETELY REMOVE URATE DEPOSITS IN THE BODY. IT WILL ALSO CONTROL HYPERURICEMIA IFGIVEN AT INTERVALS IN SMALL AMOUNTS. THERAPEUTIC URICASE SHOULD BE ABLE TO DISSOLVE URATE DEPOSITS IN A MATTER OF HOURS OR DAYS, AND SHOULD PROVIDE IMMEDIATE RELIEF FOR ACUTEGOUTY ARTHRITIS ATTACKS, WITH NO LIKELIHOOD OF RECURRENCE. CANCER PATIENTS UNDERGOING AGGRESSIVE RADIATION OR CHEMO- THERAPY AGAINST LARGE TUMOR MASSES WILL BE PROTECTED FROM EXCESSIVE URATE PRODUCTION. THE SPECIFIC AIMS OF THIS PROJECT ARE TO MODIFY BY COVALENT ATTACHMENT OF MONOMETHOXY-POLYETHYLENE GLYCOL (PEG) A SELECTED URICASE WITH HIGH ACTIVITY, GOOD STABILITY, AND CONTROLLED IMMUNOGENICITY. PROCEDURES FOR DEVELOPING A HOMOGENEOUS PEG-URICASE ARE PROCEEDING. ANIMAL TOXICOLOGY STUDIES WILL BE DONE IN MICE,RATS, AND DOGS.

* information listed above is at the time of submission.

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