THE LONG-TERM GOAL OF THIS PROJECT IS TO DEVELOP A THERA- PEUTIC URICASE THAT CAN BE USED IN HYPERURICEMIA AND THE VARIOUS MANIFESTATIONS OF GOUT, INCLUDING ACUTE AND CHRONIC GOUTY ARTHRITIS TOPHI AND URATE DEPOSITS IN TISSUES AND ORGANS, AND URIC ACID

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$43,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
4878
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Enzon Inc
Middlesex Business Center, 300-c Corporate Court, South Plainfield, NJ, 07080
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
ABRAHAM ABUCHOWSKI
PRINCIPAL INVESTIGATOR
(201) 668-1800
Business Contact:
() -
Research Institution:
n/a
Abstract
THE LONG-TERM GOAL OF THIS PROJECT IS TO DEVELOP A THERA- PEUTIC URICASE THAT CAN BE USED IN HYPERURICEMIA AND THE VARIOUS MANIFESTATIONS OF GOUT, INCLUDING ACUTE AND CHRONIC GOUTY ARTHRITIS TOPHI AND URATE DEPOSITS IN TISSUES AND ORGANS, AND URIC ACID NEPHROPATHY. IT IS EXPECTED THAT THE THERAPEUTIC URICASE WILL BE ABLE TO COMPLETELY REMOVE URATE DEPOSITS IN THE BODY. IT WILL ALSO CONTROL HYPERURICEMIA IFGIVEN AT INTERVALS IN SMALL AMOUNTS. THERAPEUTIC URICASE SHOULD BE ABLE TO DISSOLVE URATE DEPOSITS IN A MATTER OF HOURS OR DAYS, AND SHOULD PROVIDE IMMEDIATE RELIEF FOR ACUTEGOUTY ARTHRITIS ATTACKS, WITH NO LIKELIHOOD OF RECURRENCE. CANCER PATIENTS UNDERGOING AGGRESSIVE RADIATION OR CHEMO- THERAPY AGAINST LARGE TUMOR MASSES WILL BE PROTECTED FROM EXCESSIVE URATE PRODUCTION. THE SPECIFIC AIMS OF THIS PROJECT ARE TO MODIFY BY COVALENT ATTACHMENT OF MONOMETHOXY-POLYETHYLENE GLYCOL (PEG) A SELECTED URICASE WITH HIGH ACTIVITY, GOOD STABILITY, AND CONTROLLED IMMUNOGENICITY. PROCEDURES FOR DEVELOPING A HOMOGENEOUS PEG-URICASE ARE PROCEEDING. ANIMAL TOXICOLOGY STUDIES WILL BE DONE IN MICE,RATS, AND DOGS.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government