A LONG-RANGE AIM OF THIS PROPOSED WORK IS TO DEVELOP A CLINICAL TEST BASED ON PATTERNS OF NEUROTRANSMITTERS (MONOAMINES, PEPTIDES/PRECURSORS, METABOLITES, AND CONJUGATES) WHICH CAN BE USED TO GUIDE AND DEVELOP THERAPY AND PREDICT OUTCOME IN PATIENTS WITH

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
3289
Agency Tracking Number:
3289
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
45 Wiggins Ave., Bedford, MA, 01730
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
WAYNE R. MATSON
PRINCIPAL INVESTIGATOR
(617) 275-0101
Business Contact:
() -
Research Institute:
n/a
Abstract
A LONG-RANGE AIM OF THIS PROPOSED WORK IS TO DEVELOP A CLINICAL TEST BASED ON PATTERNS OF NEUROTRANSMITTERS (MONOAMINES, PEPTIDES/PRECURSORS, METABOLITES, AND CONJUGATES) WHICH CAN BE USED TO GUIDE AND DEVELOP THERAPY AND PREDICT OUTCOME IN PATIENTS WITH TRIGEMINAL NEURALGIA (TGM) AND OTHER FORMS OF FACIAL PAIN. NEW TECHNOLOGY INTERFACING UP TO 32 MULTIPLE ELECTRODE SENSORS WITH LIQUID CHROMATOGRAPHY (N-ELC) HAS IMPROVED THE RESOLUTION AND SENSITIVITY OF CONVENTIONAL LC TECNHIQUES BY APPROXIMATELY A FACTOR OF TWENTY, ALLOWING SIMULTANEOUS RESOLUTION OF 100200 COMPOUNDS IN DIRECTLY INJECTED CEREBROSPINAL FLUID (CSF) AT THE 0.51 PG LEVEL AND SIMULTANEOUS DETERMINATION OF MOST OF THE COMPONENTS OF MONOAMINERGIC AND PEPTIDE SYSTEMS IMPLICATED IN PAIN WITH A LIMITED NUMBER OF ANALYTICAL CONDITIONS. THE AIMS OF THE PHASE I PROPOSAL ARE TO REFINE METHODS FOR SIMULTANEOUS DETERMINATION OF MONOAMINERGIC COMPOUNDS AND PEPTIDES, TO PROVIDE AN INITIAL BODY OF DATA ON LEVELS OF MONOAMINES AND PEPTIDES IN CSF FROM THE TRIGEMINAL CISTERNS AND POSTERIA FOSSA OF TGM AND OTHER FACIAL PAIN SUBJECTS, AND TO COMPARE THE DATA WITHIN SUBJECTS FOR THE TWO DIFFERENT SAMPLE TYPES AND AMONG SUBJECTS FOR DIFFERENT DIAGNOSIS OF FACIAL PAIN FOR SIGNIFICANT VARIATIONS.

* information listed above is at the time of submission.

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