METHODS FOR KYNURENINE SYSTEM IN HUNTINGTON'S DISEASE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1989
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
5303
Agency Tracking Number:
5303
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
45 Wiggins Avenue, Bedford, MA, 01730
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Wayne R Matson
Principal Investigator
(617) 275-0100
Business Contact:
() -
Research Institute:
n/a
Abstract
PROTOTYPE MULTIPLE ELECTRODE LIQUID CHROMATOGRAPHY (N-ELC) SYSTEMS HAVE BEEN DEVELOPED FOR SIMULTANEOUS ANALYSIS OF SEVERAL HUNDRED COMPONENTS IN BIOLOGICAL SAMPLES AT THE FEMTOGRAM LEVEL. A MAJOR MARKET FOR N-ELC SYSTEMS DEPENDS ON THE DEMONSTRATION OF THE RELEVANCE OF MULTICOMPONENT MEASUREMENTS TO DEGENERATIVE NEUROLOGICAL DISORDERS. RECENTLY, QUINOLINIC ACID (QA) HAS BEEN SHOWN TO REPLICATE THE HISTOLOGICAL AND NEUROCHEMICAL FEATURES OF HUNTINGTON'S DISEASE (HD), A PROGRESSIVE DEGENERATIVE NEUROLOGICAL DIS- ORDER. ESA WILL DEVELOP AND APPLY N-ELC METHODS FOR THE ANALYSIS OF THE KYNURENINE (KY) PATHWAY LEADING TO THE QA. THE INTENT IS TO DEVELOP PROCEDURES CAPABLE OF LOCATING A METABOLIC DEFECT IN HD LEADING TO INCREASED QA ACCUMULATION.SIMULTANEOUSLY, THE N-ELC PROCEDURES WILL PROVIDE INFORMA- TION ON THE APPROXIMATELY 40 OTHER COMPONENTS OF THE TYROSINE AND TRYPTOPHAN PATHWAYS. THESE DATA WILL BE USED TO QUALIFY THE KY PATHWAY AND IMPROVE INTERCLASS CORRELA- TIONS BETWEEN HD AND NORMALS. AS PART OF AN ONGOING PROGRAMAT MGH, THE SAMPLES WILL ALSO BE ASSAYED FOR QA, AMINO ACIDS, AND NEUROPEPTIDES. THE LONG-RANGE AIM OF THE PROJECTIS TO DEFINE THE NEUROCHEMICAL PATHWAYS IN HD IN SUFFICIENT DETAIL TO GUIDE PHARMACOLOGICAL INTERVENTION.

* information listed above is at the time of submission.

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