MULTIPARAMETER METABOLIC PATTERN INFECTION DIAGNOSIS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
7222
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Esa Inc
45 Wiggins Avenue, Bedford, MA, 01730
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
WAYNE R MATSON PHD
(617) 275-0100
Business Contact:
() -
Research Institution:
n/a
Abstract
CONTINUOUS AMBULATORY PERITONEAL DIALYSIS (CAPD) IS NOW RECOGNIZED AS A FEASIBLE ALTERNATIVE FOR HEMODIALYSIS IN END-STAGE RENAL FAILURE. THE RAPID AND POTENTIALLY LETHAL DEVELOPMENT OF PERITONITIS IS A MAJOR LIMITATION AND CONCERNFOR THE CAPD PHYSICIAN AND PATIENT. CURRENT CONVENTIONAL TECHNIQUES FOR CULTURING, DETECTING, AND CLASSIFYING INFECTION IN CAPD ARE NOT FULLY ADEQUATE TO TREAT PERITONITIS. THE RECENT DEVELOPMENT OF COMPUTERIZED, MULTIPLE ELECTROCHEMICAL SENSOR CHROMATOGRAPHY TECHNOLOGY (N-ELC) OFFERS A ROUTE TO A RAPID INSTRUMENTAL DIAGNOSIS OF CAPD INFECTION THROUGH THE DETECTION OF UNIQUE, SMALL-MOLECULE PATHOGEN METABOLITES. CURRENT N-ELC TECHNOLOGY TAKES 60 MINUTES TO SEPARATE AND CAN DETECT APPROXIMATELY 250 COMPOUNDS IN PERITONEAL DIALYSATE AT FEMTOGRAM SENSITIVITIES. PRELIMINARY WORK HAS INDICATED THAT 6 TO 8 OF THESE ARE ASSOCIATED WITH INFECTION. THE PROPOSED WORK INVOLVES VERIFICATION AND IDENTIFICATION OF UNIQUE MARKERS AND THE DEVELOPMENT OF RAPID N-ELC TESTINGPROTOCOLS TO OPEN A MARKET FOR THE CURRENT N-ELC RESEARCH EQUIPMENT IN INFECTIOUS DISEASES.

* information listed above is at the time of submission.

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