PROCESS FOR MAKING ETHYL DIHYDROXYBUTYRATE AND ETHYL GLYCOLATE FROM STARCH

Award Information
Agency:
Department of Agriculture
Branch
n/a
Amount:
$50,000.00
Award Year:
1994
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
26925
Agency Tracking Number:
26925
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Po Box 27008, East Lansing, MI, 48909
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr Carl W Niekamp
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
THE INCREASE IN THE NUMBER OF PURE SINGLE ENANTIOMER DRUG PRODUCTS ENTERING THE MARKET HAS BEEN SPURRED ON BY THE RECENT CHANGE IN THE FDA'S DRUG GUIDELINES. THIS CHANGE HAS CREATED A LARGE DEMAND FOR OPTICALLY-PURE, CHIRAL SYNTHONS OR BUILDING BLOCK INTERMEDIATES BY THE PHARMACEUTICAL COMPANIES. ETHYL (S)-3,4-DIHYDROXYBUTYRATE, A NEW COMMERCIAL PRODUCT, IS A PROMISING, VERSATILE, CHEMICAL INTERMEDIATE SUITABLE FOR A NUMBER OF SINGLE ENANTIOMER DRUG APPLICATIONS. IN ADDITION, ETHYL GLYCOLATE, A CO-PRODUCT, IS AN IMPORTANT BUILDING BLOCK FOR THE PREPARATION OF MEDICINAL COMPOUNDS AND AGROCHEMICALS. TODAY THE CHEMICAL PRESURSOR MOLECULES, (S)-3,4-DIHYDROXYBUTYRIC ACID AND GLYCOLIC ACID, ARE MADE FROM PETROLEUM-DERIVED RAW MATERIALS. THESE PROCESSES USE TOXIC FEEDSTOCKS AND ORGANIC SOLVENTS IN THEIR RECOVERY STEPS. THE PROPOSED RESEARCH WILL CREATE A UNIQUE MANUFACTURING PROCESS WHICH USES A NON-TOXIC, FOOD GRADE STARCH PRODUCT AS THE STARTING MATERIAL AND ALL AQUEOUS PROCESS UP TO THE FINAL ESTERIFICATION STEP. THE PROPOSED MANUFACTURING PROCESS REPRESENTS AN OPPORTUNITY TO PAVE THE WAY FOR THE INTRODUCTION OF A WHOLE FAMILY OF OPTICALLY-PURE, CHIRAL SYNTHONS, OF WHICH ETHYL (S)-3,4-DIHYDROXYBUTYRATE IS A PRACTICAL MODEL PRODUCT, AND NATURAL ETHYL GLYCOLATE IS A VALUABLE DERIVATIVE.

* information listed above is at the time of submission.

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