CARRAGEENAN IMMOBILIZATION OF GLUCOSE ISOMERASE

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: N/A
Agency Tracking Number: 5286
Amount: $40,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
2020 W. Main Street, Suite 40, Durham, NC, 27705
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
 Robert W. Henkens
Title: Chairman
Phone: () -
Research Institution
N/A
Abstract
IMMOBILIZED FORMS OF ENZYMES HAVE OUTSTANDING PROMISE AS INDUSTRIAL CATALYSTS TO MAKE OR MODIFY PRODUCTS; AND ADVANCES IN IMMOBILIZED ENZYME TECHNOLOGY CAN HAVE A MAJOR ECONOMIC IMPACT ON THE PRODUCTION OF FOODS AND OTHER MATERIALS. ENZYME TECHNOLOGY RESEARCH GROUP, INC. IS DESIGNING THE DEVELOPING UNIQUE CARRAGEENAN-BASED SUPPORTS FOR IMMOBILIZED ENZYMES. THE OBJECTIVE OF THIS PROJECT IS TO DESIGN AND DEVELOP A GREATLY IMPROVED IMMOBILIZED FORM OF GLUCOSE ISOMERASE THAT OVERCOMES DEFICIENCIES OF CURRENT PRODUCTS. CARRAGEENAN AND GLUCOSE ISOMERASE WILL BE USED TO PRODUCE A SOPHISTICATED MATERIAL WITH UNIQUE PROPERTIES THAT CAN BE TRANSLATED INTO GREATLY IMPROVED PLANT PERFORMANCE IN THE ISOMERIZATION OF GLUCOSE TO PRODUCE HIGH-FRUCTOSE SYRUP. THE OBJECTIVE IS TO INCREASE PRODUCTIVITY (AMOUNT OF FRUCTOSE PRODUCED PER UNIT OF ENZYME) AND YIELD UP TO 55% FRUCTOSE. RESEARCH WILL BE CARRIED OUT ON GLUCOSE ISOMERASE IMMOBILIZED ON THREE CARRAGENAN-BASED SUPPORT MATERIALS. THE RESEARCHERS WILL MEASURE THE EFFECTS OF PH AND TEMPERATURE ON THE STABILITY AND ACTIVITY OF THE ENZYME; DETERMINE SENSITIVITY TO O2 INACTIVATION AND CA++ INHIBITION; AND MEASURE THE FRUCTOSE YIELD UNDER OPTIMUM CONDITIONS FOR PRODUCTIVITY.

* Information listed above is at the time of submission. *

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