CARRAGEENAN IMMOBILIZATION OF GLUCOSE ISOMERASE

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$40,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
5286
Agency Tracking Number:
5286
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2020 W. Main Street, Suite 40, Durham, NC, 27705
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
Robert W. Henkens
Chairman
() -
Research Institution:
n/a
Abstract
IMMOBILIZED FORMS OF ENZYMES HAVE OUTSTANDING PROMISE AS INDUSTRIAL CATALYSTS TO MAKE OR MODIFY PRODUCTS; AND ADVANCES IN IMMOBILIZED ENZYME TECHNOLOGY CAN HAVE A MAJOR ECONOMIC IMPACT ON THE PRODUCTION OF FOODS AND OTHER MATERIALS. ENZYME TECHNOLOGY RESEARCH GROUP, INC. IS DESIGNING THE DEVELOPING UNIQUE CARRAGEENAN-BASED SUPPORTS FOR IMMOBILIZED ENZYMES. THE OBJECTIVE OF THIS PROJECT IS TO DESIGN AND DEVELOP A GREATLY IMPROVED IMMOBILIZED FORM OF GLUCOSE ISOMERASE THAT OVERCOMES DEFICIENCIES OF CURRENT PRODUCTS. CARRAGEENAN AND GLUCOSE ISOMERASE WILL BE USED TO PRODUCE A SOPHISTICATED MATERIAL WITH UNIQUE PROPERTIES THAT CAN BE TRANSLATED INTO GREATLY IMPROVED PLANT PERFORMANCE IN THE ISOMERIZATION OF GLUCOSE TO PRODUCE HIGH-FRUCTOSE SYRUP. THE OBJECTIVE IS TO INCREASE PRODUCTIVITY (AMOUNT OF FRUCTOSE PRODUCED PER UNIT OF ENZYME) AND YIELD UP TO 55% FRUCTOSE. RESEARCH WILL BE CARRIED OUT ON GLUCOSE ISOMERASE IMMOBILIZED ON THREE CARRAGENAN-BASED SUPPORT MATERIALS. THE RESEARCHERS WILL MEASURE THE EFFECTS OF PH AND TEMPERATURE ON THE STABILITY AND ACTIVITY OF THE ENZYME; DETERMINE SENSITIVITY TO O2 INACTIVATION AND CA++ INHIBITION; AND MEASURE THE FRUCTOSE YIELD UNDER OPTIMUM CONDITIONS FOR PRODUCTIVITY.

* information listed above is at the time of submission.

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