Thioaptamer Diagnostic System

Award Information
Agency: National Aeronautics and Space Administration
Branch: N/A
Contract: NNX10CA98C
Agency Tracking Number: 084457
Amount: $600,000.00
Phase: Phase II
Program: SBIR
Awards Year: 2010
Solicitation Year: 2008
Solicitation Topic Code: X10.01
Solicitation Number: N/A
Small Business Information
12521 Gulf Freeway, HOUSTON, TX, 77034-4509
DUNS: 788679244
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Xianbin Yang
 Principal Investigator
 (832) 379-2175
 xianbin.yang@thioaptamer.com
Business Contact
 Mark Shumbera
Title: Business Official
Phone: (832) 295-1483
Email: mark.shumbera@thioaptamer.com
Research Institution
N/A
Abstract
AM Biotechnologies (AM) in partnership with Sandia National Laboratories will develop a Thioaptamer Diagnostic System (TDS) in response to Topic X10.01 Reusable Diagnostic Lab Technology. The TDS will quickly quantify clinically relevant biomarkers in flight using only microliters of virtually any complex sample. The system combines ambient-stable, long-shelf-life affinity agent assays with a handheld microfluidic gel electrophoresis affinity assay quantification technology. The system is easy to use, compatible with operation in microgravity, and designed to permit simultaneous quantification of 32 or more biomarkers from a single astronaut sample. Phase 1 of this project demonstrated that a thioaptamer assay used in the microfluidic instrument can quantify a specific biomarker in serum in the low nanomolar range. AM also successfully identified novel affinity agents to bone specific alkaline phosphatase (BAP) and demonstrated their use to detect BAP using the microfluidic instrument. Phase 2 will expand the number of ambient stable affinity agents and demonstrate a TDS prototype to NASA. AM anticipates that the TDS at the end of Phase 2 will be at TRL 4 to 5. In Phase 3, AM and Sandia will produce flight units for NASA research use on the International Space Station (ISS) as well as for diagnostic use on future long duration missions.

* Information listed above is at the time of submission. *

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