Rapid Detection Nano-Sensors for Biological Warfare Agents in Buildings and HVAC Systems

Award Information
Agency: Department of Defense
Branch: Army
Contract: W9132T-06-C-0032
Agency Tracking Number: A064-026-0064
Amount: $99,961.00
Phase: Phase I
Program: STTR
Awards Year: 2006
Solicitation Year: 2006
Solicitation Topic Code: A06-T026
Solicitation Number: N/A
Small Business Information
EPIR TECHNOLOGIES INC
590 Territorial Drive, Suite B, Bolingbrook, IL, 60440
DUNS: 068568588
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 James Garland
 (630) 771-0203
 jgarland@epir.com
Business Contact
 Sivalingam Sivananthan
Title: President
Phone: (630) 771-0201
Email: ssivananthan@epir.com
Research Institution
 UNIV. OF ILLINOIS AT CHICAGO
 Michael Stroscio
 Science and Engineering Offic
Chicago, IL, 60607
 (312) 413-5968
 Nonprofit college or university
Abstract
Currently there is no real-time technology to detect airborne biological warfare agents (BWAs). Conventional technologies require 30 minutes to 1 hour. We propose to design, fabricate and test user-friendly, low-logistical-load biosensors capable of the real-time (~ 30 s. or less) detection and identification of airborne BWAs with high sensitivity and specificity for all classes of bioagents – bacterial spores, viruses, vegetative bacteria, and bacterial toxins – and many chemical agents. The biosensors developed will be easily used within building infrastructures, in particular HVAC systems. They will be user-friendly, have low-logistical-loads (i.e., reagents and consumables), and will allow the quantification of the density of airborne BWAs. They will allow automated remote response and the automated refreshing of antibodies and filters. They will utilize standard biofluidic techniques augmented with quantum-dot technology and optoelectronic techniques. They will incorporate two, or possibly three, different techniques for the detection and identification of BWAs: (1) the localization of antigens on grids having different pore sizes, (2) the tagging of these antigens with antibody-QD complexes and the observation of photoluminescence from the QDs bound to the localized antigens, and (3) for chemical agents and possibly small antigens, observing FRET between QDs and dies bound to the same antigen.

* information listed above is at the time of submission.

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