Dual Formulation of Atropine and Scopolamine with Enhanced Stability

Dual Formulation of Atropine and Scopolamine with Enhanced Stability

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911QY-18-C-0216
Agency Tracking Number: C181-005-0045
Amount: $149,756.40
Phase: Phase I
Program: SBIR
Awards Year: 2019
Solicitation Year: 2018
Solicitation Topic Code: CBD181-005
Solicitation Number: 2018.0
Small Business Information
Dual Formulation of Atropine and Scopolamine with Enhanced Stability, Cambridge, MA, 02138
DUNS: 557201394
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Xinhua Li
 (617) 621-8500
 xli@nanoterra.com
Business Contact
 Peter Howe
Phone: (617) 621-8500
Email: phowe@nanoterra.com
Research Institution
N/A
Abstract
The standard US military treatment for nerve agent exposure is application of up to three autoinjectors, each containing atropine sulfate and2-pralidoxime, to counteract symptoms of nerve agent intoxication and restore acetylcholinesterase activity. This treatment increases survivalrates after nerve agent exposure, however, seizures resulting from nerve agent poisoning are a common symptom that can prolong recoveryand reduce survival rates. The motion-sickness drug scopolamine hydrobromide, has been demonstrated as an effective treatment forreducing seizures and enhancing survival and recovery from nerve agent exposure. A single autoinjector with a combined formulation ofatropine and scopolamine would be extremely beneficial to our warfighters and first responders; however, a stable dual formulation ofatropine and scopolamine has not been demonstrated. We propose to develop stable dual formulations of atropine sulfate and scopolaminehydrobromide. The dual formulations containing both drugs will be stable for a minimum of 2 years with a volume of 2 mL or less.

* Information listed above is at the time of submission. *

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