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Mycotoxin Adsorption with Hemocompatible Porous Polymer Beads

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911QY-17-C-0007
Agency Tracking Number: C2-0443
Amount: $999,996.59
Phase: Phase II
Program: SBIR
Solicitation Topic Code: CBD152-003
Solicitation Number: 2015.2
Solicitation Year: 2015
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-02-01
Award End Date (Contract End Date): 2019-01-31
Small Business Information
7 Deer Park Drive, Suite K
Monmouth Junction, NJ 08852
United States
DUNS: 830014077
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Phillip Chan, MD, PhD
 Chief Executive Officer
 (732) 329-8885
Business Contact
 James Cason
Phone: (732) 329-8885
Research Institution

Certain species of fungi produce mycotoxins, which can cause acute toxicity and even death in human that either have been, or potentiallycould be, used by bioterroists as weapons of mass destruction. Aflatoxin and trichothecene T-2 toxin are two mycotoxins that are of particularconcern as potential biological weapons due to their toxicity, environmental stability, easy accessibility, historical production for use inbiowarfare and lack of specific therapy. We propose applying our broad spectrum hemoadsorbent CytoSorb as a medical countermeasure. Wehypothesize that hemoadsorption will have a significant impact on survival by directly reducing the toxin level as well as reducing the levels ofdamage-associated molecules released into circulation. During the Phase I, we demonstrated the ability of CytoSorb to efficiently remove>99% of the aflatoxin and T-2 toxin from whole blood in vitro. For Phase II we propose in vivo studies to demonstrate the efficacy our polymerin reducing systemic toxicity caused by mycotoxins. Further we proposed advancing the development of our hemoadsorption device to meetmilitary supply logistics. The outcome will be the demonstration of a safe and effective method for removal of aflatoxin and T-2 toxin fromblood, a currently unaddressed area of relevance for biowarfare defense.

* Information listed above is at the time of submission. *

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