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Dermal Medical Countermeasures for Chemical Weapons Exposure

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: HDTRA1-18-C-0043
Agency Tracking Number: C2-0489
Amount: $983,423.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: CBD161-003
Solicitation Number: 2017.0
Timeline
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-09-28
Award End Date (Contract End Date): 2020-09-27
Small Business Information
104 T.W. Alexander Dr. Bldg 5 STE 505 P.O. Box 12072, Durham, NC, 27709
DUNS: 080123728
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Zhigang Liu
 (646) 691-8050
 michael.liu@zymeron.com
Business Contact
 Michael Liu
Phone: (646) 691-8050
Email: sbir@zymeron.com
Research Institution
N/A
Abstract
The skin is the first line of defense against chemical warfare agents including nerve agents and toxic industrial chemicals, providing a possible barrier or delay to systemic distribution. Some chemicals also can act directly on the skin including the vesicants sulfur mustard and lewisite. Early and rapid skin decontamination is extremely important following exposure to CWAs and TICs because it decreases serious systemic and dermal damage. Current formulations of dermal medical countermeasures such as reactive skin decontamination lotion (RSDL) are only approved by the FDA for small area applications on intact skin. This severely restricts its usefulness since warfighters may be exposed over large areas of the body including wound or skin abrasion sites. Zymeron proposes to develop a thermally stable, broad spectrum skin decontamination product that overcomes the major obstacles of RSDL. The decon formulation will be demonstrated by a tiered evaluation approach involving the use of in vitro, ex vivo and in vivo assays and animal models. At the end of Phase II, the dermal decon formulation will be ready for IND-enabling GLP studies.

* Information listed above is at the time of submission. *

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