Diagnostic Reagents for Emerging Infectious Diseases

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 1R43AI050262-01
Amount: $105,609.00
Phase: Phase I
Program: SBIR
Awards Year: 2001
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
Phone: (401) 272-2123
Research Institution
DESCRIPTION (provided by applicant): West Nile virus (WNV) is a flavivirus commonly found in Africa, West Asia, and the Middle East. The virus was introduced into the United States in 1999. Case-fatality rates during the 1999-2000 U.S. epidemics ranged from 3 percent to 15 percent and were highest in the elderly. The virus is expected to over-winter during 2000-2001 and re-emerge in the Northeast over a wider area. The goal of this project is to develop epitope reagents that could be used in a diagnostic test (such as a tetramer assay) for cell-mediated response to WNV. These reagents may be useful for screening exposed individuals, for investigating the immunopathogenesis of WNV disease in humans, as a component of the surveillance effort and/or, eventually, as a tool for measuring WNV vaccine-related immune responses. The specific aims of this project are to: Select WNV "unique" sequences for potential immunogenicity, using EpiVax tools Confirm MHC binding of selected ligands in T2 MHC binding assays Confirm T cell response to the WNV epitopes by ELIspot assay Begin the process of constructing several tetramers containing WNV epitopes with the NIH tetramer contract service. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

* information listed above is at the time of submission.

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