A Novel Catheter Enterogenesis Device to Treat Short Bowel Syndrome

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$120,458.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
1R43DK085765-01A1
Award Id:
96030
Agency Tracking Number:
DK085765
Solicitation Year:
n/a
Solicitation Topic Code:
NIDDK
Solicitation Number:
n/a
Small Business Information
MC3, INC., 3550 W LIBERTY RD, STE 3, ANN ARBOR, MI, 48103
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
806687406
Principal Investigator:
PHILIP WONG
() -
Business Contact:
KATHRYN OSTERHOLXER
() -
koster@mc3corp.com
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): Abstract Short bowel syndrome (SBS) represents a loss of sufficient length of intestine compromising the absorption of nutrients and fluids to sustain life. Although patients may be maintained on parenteral (intravenous ) nutrition, the morbidity can be devastating and associated mortality rates exceed 30%. Care for each SBS patient is in excess of 250,000 per year, and estimated costs for just the first five years of the care of a child with SBS exceed 1.5 million dolla rs (corrected to 2005 U.S. dollars). Recently, we have pioneered the application of longitudinal distractive forces, as directed with an intraluminally placed device, to induce intestinal growth - enterogenesis. We have demonstrated significant lengthening of pig small intestine (2.7-fold) over a 10-day period. The lengthening is not merely a stretching of the intestine, but true growth with preservation of intestinal function. The overall goal of this research proposal is to develop a catheter based device which could be placed for days to weeks in a clinical setting to deliver linear forces to the intestine, allowing for an elongation of the intestine while keeping the continuity of the intestine intact. The catheter enterogenesis device (CED) is envisione d as a simple, effective means of improving survival for SBS sufferers. Aims are to define the requirements of the CED in terms of small bowel geometry and tissue properties, to design and build a disposable prototype and to demonstrate safe intraluminal p lacement, anchoring to the small bowel wall, delivery of distractive forces and acceptable flow of enteric material past the CED. This will pave the way to more extensive Phase 2 studies investigating chronic device application, optimizing the treatment pr otocol, demonstrating statistically significant bowel lengthening and evaluating possible complications. PUBLIC HEALTH RELEVANCE: Project Narrative The overall goal of this research proposal is to develop a catheter based device which will deliver l inear forces to the intestine, allowing for an elongation of the intestine while keeping the continuity of the intestine intact. The catheter enterogenesis device (CED) is envisioned as a simple, effective means of improving survival for short bowel syndro me sufferers.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government