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Aerosolized hyaluronic acid as a treatment for emphysema
Phone: (718) 283-7154
Phone: (787) 283-7154
Type: Nonprofit college or university
DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease
afflicts 12-14 million people in the US and in an advanced form, emphysema,
disables 2 million and ultimately leads to death. No approved, existing
treatment can arrest emphysema's progressive destruction of the lung. Exhale
Therapeutics, Inc intends to develop and commercialize aerosolized hyaluronic
acid (HA) into the first effective therapeutic product that can preserve lung
function. The long-term objectives of the proposed project (Phases I) are: (1)
to show that aerosolized low-molecular weight HA inhaled daily protects against
lung elastic fiber injury and subsequent destruction of alveoli; and (2) to
elucidate the protective mechanism. The specific aim of Phase I is to
demonstrate that in mice exposed regularly to tobacco smoke in a chamber that
simulates cigarette smoking, daily treatment with HA administered as an aerosol
significantly reduces the severity of emphysematous damage to their lungs. Two
groups of mice will smoke, the first will receive daily treatment with HA
dissolved in distilled water, and the second will receive nebulized water only.
A comparison of the mean linear intercept of lung sections of the two groups
will provide a direct quantitative measure of the protective effect of HA.
Other semi-quantitative measures will provide supporting evidence.
PROPOSED COMMERCIAL APPLICATION:
Hyaluronic acid (HA) has the potential to become an effective therapeutic agent that can
protect lung function against the chronic destruction of alveoli in emphysema. Since no
treatment for pulmonary emphysema currently exists, proof of safety and efficacy in
humans will permit rapid commercialization. The proposed research in an animal model
will accelerate the formulation of a therapeutic product for study and use in humans.
* Information listed above is at the time of submission. *